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research Topical ketoconazole: a systematic review of current dermatological applications and future developments

39 citations , January 2019 in “Journal of Dermatological Treatment”

This review found topical ketoconazole to be highly effective against Malassezia-related skin conditions, though other treatments may outperform it for Tinea and Candida infections.

research Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that type 2 immunity, especially involving ILC2 cells, helps maintain skin homeostasis by regulating the proliferation and community stability of hair follicle epithelial cells in the presence of Demodex mites.

research Demodex folliculitis

36 citations , March 2004 in “AIDS”

This case report highlights that immune reconstitution after starting HAART can lead to demodex folliculitis in HIV patients, emphasizing the need to consider it in differential diagnosis of skin eruptions.

Clinical Manifestation, Diagnosis, and Management of Notoedres Cati in a Domestic Cat: A Case Report from Armonia Pet Care, Makassar, Indonesia

research CLINICAL MANIFESTATION, DIAGNOSIS, AND MANAGEMENT OF NOTOEDRES CATI IN A DOMESTIC CAT: A CASE REPORT FROM ARMONIA PET CARE, MAKASSAR, INDONESIA

October 2025 in “Buletin Veteriner Udayana”

This case report described a young Himalayan kitten in Indonesia with notoedric mange, treated successfully with topical selamectin and sarolaner, highlighting the importance of early diagnosis and management to prevent reinfestation, especially in urban areas.

research OTITIS EXTERNA DUE TO COMPLICATION OF OTODECTES CYNOTIS, BACTERIA, AND MALASSEZIA SP. ACCOMPANIED BY SCABIOSIS IN DOMESTIC CAT

October 2023 in “Veterinary Science and Medicine Journal”

In this case report, a 2-year-old cat with bilateral otitis externa and scabiosis was treated with a combination of antiparasitic, antibiotic, antifungal, and anti-inflammatory medications, leading to significant clinical improvement after 10 days.

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Community Join

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community Reversed my hairloss without fin/min. 2023 December to 2025 April. IDK what happened.

565 upvotes 1 year ago

A user reversed hair loss using 10% sulfur soap, which reduced scalp inflammation and possibly demodex mites. The user did not use finasteride or minoxidil, suggesting inflammation may contribute to hair loss.

community Wtf have we been doing for the last 30 years

in Treatment 548 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community Horrible news, Stemson Therapeutics has shut down

193 upvotes 1 year ago

Stemson Therapeutics has shut down, disappointing those seeking a hair loss cure. Current treatments like minoxidil, finasteride, and dutasteride are discussed, with some users experiencing side effects and exploring alternatives like PP405.

community 4 months, only Minoxidil 5% ,dermarolling twice a week. hair growth results. any suggestions?

462 upvotes 1 year ago

Significant hair growth was achieved using Minoxidil 5% and dermarolling twice a week, with suggestions to add finasteride for maintenance. There is debate on when to apply Minoxidil after dermarolling to avoid irritation.

community Topical Anti Androgens detailed thread

6 upvotes 1 month ago

Users discuss the effectiveness of topical anti-androgens like RU58841, Pyri (KX826), and CB for hair loss. Some report maintenance and regrowth with Pyri, while others find limited success with RU58841 and switch to combinations like finasteride and minoxidil or minoxidil and dutasteride.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Pyrilutamide

Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in both men and women, but it is not approved for hair loss anywhere; the company reports that its China Phase III trial in men met its primary endpoint, but the data come from sponsor announcements rather than peer-reviewed journals, and long-term safety is unknown.

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn PP405

Can applying a mask with PP405 directly to thinning areas give your scalp the push it needs? No PP405 mask exists to test: PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, it is not an anti-DHT ingredient, and it is not on sale. Its registered Phase 2 trial (NCT06393452) measured safety, not regrowth, and a rinse-out mask is in any case the wrong format for reaching the follicle.

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