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Glossary Topical Antiandrogens

medications applied to skin to block androgen effects locally

Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

Related Terms

Research

5 / 1000+ results

research Postmenopausal virilization after spousal use of topical androgens

20 citations , January 2007 in “Fertility and Sterility”

This case report highlights that a postmenopausal woman experienced virilization due to unintentional transdermal absorption of testosterone from her spouse's topical androgen via shared washcloths, underscoring the importance of considering exogenous androgen exposure in similar diagnoses.

research Virilization from partner's use of topical androgen in a reproductive-aged woman

7 citations , April 2011 in “American journal of obstetrics and gynecology”

This case report highlights the importance of considering exogenous androgen exposure, such as transdermal testosterone cream used by a partner, in the diagnosis of virilization among women.

research Efficacy and Safety of a Topical Botanical in Female Androgenetic Alopecia: A Randomized, Single-Blinded, Vehicle-Controlled Study

6 citations , November 2017 in “Skin appendage disorders”

This study found that a new topical botanical lotion significantly increased hair density and improved quality of life in women with androgenetic alopecia over 24 weeks.

A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

research A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers

50 citations , July 2014 in “International Journal of Clinical Pharmacology and Therapeutics”

This study found that both topical and oral finasteride significantly reduced plasma DHT after one week, with lower finasteride plasma exposure for the topical formulation.

research Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature

13 citations , June 2020 in “Journal of Dermatological Treatment”

This review discusses the pharmacology and safety of topical finasteride for treating androgenetic alopecia and female pattern hair loss, noting positive results but reporting no new clinical findings.

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Community Join

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community Topical Anti Androgens detailed thread

6 upvotes 1 month ago

Users discuss the effectiveness of topical anti-androgens like RU58841, Pyri (KX826), and CB for hair loss. Some report maintenance and regrowth with Pyri, while others find limited success with RU58841 and switch to combinations like finasteride and minoxidil or minoxidil and dutasteride.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 14 upvotes 1 year ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Topical anti-androgen availability in Australia

in Product 2 years ago

Availability of topical anti-androgens, especially RU58841, in Australia. Issues with customs seizures and lack of credible local sources.

community Are topical anti-androgens (spironolactone, clascoterone, RU58841) sold/available in Egypt?

2 upvotes 1 day ago

Topical anti-androgens like spironolactone, clascoterone, and RU58841 are not readily available in Egypt, with inconsistent availability through online platforms. Minoxidil is commonly found in local pharmacies, while dutasteride is available as "Avodart" but is expensive.

community Cheap topical anti-androgens recommendations?

5 upvotes 9 months ago

The conversation is about finding affordable topical anti-androgens for hair loss. The user is currently using finasteride, dutasteride, and oral minoxidil, and is advised that additional topical treatments may not be necessary.

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Learn

8 / 29 results

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

How does spironolactone help reduce hair loss when used in topical or oral treatments? Studies report that spironolactone slows androgen-driven follicle miniaturisation by blocking androgen receptors, with most evidence in women and mostly alongside minoxidil; it is a prescription drug and its use for hair loss is off-label.

learn Pyrilutamide

What is pyrilutamide, and how does it help with androgenic alopecia or hair loss caused by DHT? Pyrilutamide (KX-826) is an investigational topical antiandrogen designed to block DHT at the androgen receptor in the scalp rather than lower DHT in the blood. Its sponsor has announced positive Phase III top-line results in China, but none of the data are peer-reviewed and it is not approved as a medicine anywhere.

learn Fluridil

a topical anti-androgen with less systemic involvement

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

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