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Research

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research Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

9 citations , January 2022 in “Theranostics”

This review discusses the role of collagen XVII in maintaining stem cell niches and its impact on skin aging and wound repair, without reporting new clinical results.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

research Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.

research Faculty Opinions recommendation of Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.

September 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

This study found that lymphatic vessels play a crucial role in hair follicle growth and regeneration in mice by connecting hair follicles and expanding during stem cell activation.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.

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Community Join

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community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 year ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 245 upvotes 1 year ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

community Now that hair loss in mice is solved, can they move on to people?

709 upvotes 6 months ago

Hair loss treatments are being tested on mice, with methods like minoxidil and stem cell therapy showing promising results. However, human trials are still years away, leading to humorous frustration about mice benefiting first.

community Tretinoin vs. micro-needling: what increases sulfotransferase activity more?

in Research/Science 1 upvotes 1 year ago

Tretinoin and microneedling both enhance hair growth through different mechanisms, with microneedling being considered safe for long-term use. Optimal microneedling needle length varies, but 0.8 mm is suggested for hair growth, and a Dermastamp is recommended to avoid skin damage.

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Clinics

6 / 23 results

Learn

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learn Stem Cell Factor

Are stem cell factor products safe for long-term scalp use? Long-term safety of stem cell factor scalp products has not been studied in people; the one human trial of injected stem cell factor reported skin reactions and lasting dark patches.

learn vitamin b2

What role does Vitamin B2 (Riboflavin) play in maintaining healthy hair follicles? Riboflavin (vitamin B2) is needed for normal cell energy metabolism, and severe deficiency can affect the skin. A 2019 review found no good evidence that extra B2 helps hair in people who are not deficient.

learn Microneedling

Technique that makes tiny skin punctures; studied mainly as an add-on to minoxidil for pattern hair loss, with low-quality evidence. No device is FDA-cleared for hair loss.

learn Dexpanthenol

Provitamin B5 used in hair and skin products as a moisturiser; evidence for hair growth is limited to lab studies and small uncontrolled reports.

learn GHK-Cu

What is GHK-Cu and why is it said to be a "miracle" for hair? GHK-Cu is a copper peptide studied mainly for wound healing and skin repair; for hair loss the evidence stops at cell-culture and animal work, and no published human trial has tested it for androgenetic alopecia.

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Experts

1 / 3 results

SMP Specialist
Noelle Skin
Nice, France

Noelle Skin