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This study reports the discovery of LX-38, a new high-affinity non-steroidal antagonist that could provide the therapeutic benefits of current BPH and AGA treatments without the hormonal side effects, utilizing a distinct "Orthogonal T-Stacking" scaffold for binding.

This study found that tofacitinib was safe and effective for patients with severe or treatment-resistant alopecia areata, alopecia totalis, and alopecia universalis, resulting in significant hair regrowth for most participants.

A test for nail fungus was most accurate with PAS stain, low-dose spironolactone helped two-thirds of acne patients, metformin reduced symptoms of HIV-related fat distribution changes with some side effects, and skin examination with dermoscopy was better at detecting abnormal moles, while temporary tattoos can cause skin reactions.

This article reviews trichotillomania, highlighting its differences from OCD and recommending treatments like habit reversal therapy and specific medications, but reports no new clinical results.

In this study, trilostane treatment led to complete hair re-growth in 85% of Pomeranians and all miniature poodles with alopecia X within 4 to 8 weeks.

In this study, leflunomide was effective in treating rheumatoid arthritis, showing comparable efficacy to methotrexate and greater response rates than sulfasalazine, but has significant side effects that require monitoring.

This study found that seniors using finasteride or dutasteride for benign prostatic hyperplasia may have an increased risk of depression and self-harm, especially during the first 18 months of treatment.

This study found that androgenetic alopecia in men is associated with significant psychological distress and moderate depression, suggesting a possible link between raised dihydrotestosterone levels and mental health issues.

This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.

In this reported case of SAPHO syndrome, methotrexate treatment led to significant clinical improvement after other treatments for skin lesions and arthritis proved less effective.

The trial helped find the best dose of deuruxolitinib for treating alopecia areata.

This study reports the discovery of LX-38, a novel non-steroidal drug candidate that may offer safer treatment for conditions like Benign Prostatic Hyperplasia by avoiding hormonal side effects associated with current therapies.

This correspondence discusses clascoterone as a potential new treatment for androgenetic alopecia but reports no clinical results.

This study reviews current treatments for PCOS and evaluates Tirzepatide as a potential option for its management, suggesting possible benefits for those with obesity and metabolic syndrome but not for those of normal weight.

This study found significant signals of sexual dysfunction associated with finasteride use, particularly in younger patients treated for alopecia, though confounding factors may partly contribute to reported cases.

This review discusses the sexual side effects of long-term finasteride usage in men, noting varied reports of sexual dysfunction which typically improve over time; it presents no new experimental data.

In this study, pioglitazone treatment in insulin-resistant PCOS patients decreased relative 5alpha-reductase activity without significantly affecting cortisol levels or urinary cortisol excretion.

This study reviewed recent scientific evidence on the neuroendocrine and metabolic impacts of chronic use of 5-alpha reductase inhibitors, detailing its association with sexual dysfunction, mood disorders, insulin resistance, and other metabolic disorders, suggesting persistent biopsycho-social risks beyond transient side effects in users.

This study evaluated dermatologists' beliefs and counseling practices regarding finasteride's adverse effects, revealing that while 51% believed it could cause sexual side effects, fewer associated it with depression or infertility, highlighting a need for increased awareness and improved patient counseling.

This study found that blocking neurosteroid synthesis in pregnant sheep increased HPA axis activity, particularly under stress, suggesting neurosteroids help modulate stress response.

This study found that clobetasol propionate 0.05% was more effective than topical metformin 30% in treating localized alopecia areata, even though both treatments were generally well-tolerated and showed similar effects overall.

Testosterone reduces, while finasteride enhances, morphine's pain relief.

This report suggests that tofacitinib may be beneficial for patients with nail disease unresponsive to other treatments.

In this prospective study of 135 women with hirsutism, researchers reported that treatment approaches varied, with oral contraceptives, dexamethasone, and metformin widely used, and emphasized a holistic approach including lifestyle changes and mental health support to effectively manage the condition.

This retrospective cohort study reported that oral tofacitinib was effective in treating alopecia areata, with 83.2% of patients showing improvement and 16.0% achieving complete remission. Earlier intervention and previous hair regrowth were linked to better outcomes, and no severe adverse events were observed.

This study observed that administering 1000 mg/kg of LSFP significantly reduced serum FSH and LH levels and testicular index in male Wistar rats, while lower doses showed no such effect.

This review found that fulvestrant is well tolerated in postmenopausal women with hormone receptor-positive advanced breast cancer, showing lower incidence of joint disorders than non-steroidal aromatase inhibitors.

This article discusses finasteride and dutasteride use for androgenetic alopecia in light of recent concerns over persistent erectile dysfunction but provides no new clinical findings.