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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Cathepsin L is essential for normal hair growth and development.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

Methotrexate reduced the need for steroids in asthma patients without worsening their condition.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

Researchers found a new gene, hacl-1, that is active in mouse hair follicles during hair growth and may be important for hair biology.

Some plants with flavonoids may help treat hair loss and promote hair growth.

C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Adding more glutathione to the preservation solution doesn't reduce oxidative stress in hair transplants.

Involucrin helps strengthen the inner parts of human hair.

Bariatric surgery improves skin conditions and metabolism but may cause nutritional deficiencies and hair loss.

Ingenol mebutate gel changes gene expression related to skin development and immune response in actinic keratosis.

Xeno-free three-dimensional stem cell masses are safe and effective for improving blood flow and tissue repair in limb ischemia.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Single-cell engineered biotherapeutics show promise for skin treatment but need more research and trials.

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

Blue light might help treat skin conditions by affecting the skin's bacteria.

Isotretinoin affects trace element levels and requires monitoring of liver and kidney functions.

A woman with lupus had rare severe symptoms but improved with treatment.

The document concludes that in Sri Lanka, 25 common plants are traditionally used as home remedies for various health issues due to their medicinal properties.

Valproic acid does not change biotinidase enzyme activity in children's blood.