Quality of Life Measurement in Alopecia Areata: Position Statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient-Oriented Outcomes

June 2021 in “ Journal of the European Academy of Dermatology and Venereology ”

Pavel V. Chernyshov, Lucía Tomás‐Aragonés, A.Y. Finlay, L. Manolache, S.E. Marrón, Francesca Sampogna, Saskia Spillekom‐van Koulil, Nives Pustišek, Alina Suru, Andrea W.M. Evers, Carmen Sălăvăstru, Åke Svensson, Damiano Abeni, Christine Blome, F. Poot, Gregor B. E. Jemec, Dennis Linder, Matthias Augustin, Anthony Bewley, Sam Salek, Jacek C. Szepietowski

alopecia areata Dermatology Life Quality Index DLQI Scalpdex Alopecia Areata Symptom Impact Scale Alopecia Areata Quality of Life Index

Studysummary This review highlights current knowledge about quality of life assessment in alopecia areata, noting limited use of existing instruments and a need for further validation.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing Its Impact on T Regulatory Cell and NK Cell Populations

22 citations , September 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review highlights the possible role of T regulatory cells in the immune-related mechanisms of alopecia areata but reports no new clinical findings.

‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

30 citations , September 2020 in “Journal of Patient-Reported Outcomes”

This study found that alopecia areata significantly impacts emotional and psychological well-being, relationships, and lifestyles, highlighting the need for increased awareness and effective treatments.

research JAK Inhibitors for the Treatment of Alopecia Areata

4 citations , January 2020 in “PubMed”

This source reports that JAK inhibitors, such as ruxolitinib, baricitinib, and tofacitinib, have led to hair regrowth in alopecia areata patients and animal models, but their long-term safety and effectiveness remain uncertain, with ongoing trials to further investigate these factors.

research JAK Inhibition in the Treatment of Alopecia Areata: A Promising New Dawn?

29 citations , December 2019 in “Expert review of clinical pharmacology”

This review discusses the evidence supporting Janus kinase inhibitors for alopecia areata and highlights ongoing optimism as phase 3 trials begin, with no new clinical results reported.

Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression, with Alopecia Areata in Males: A Case-Control Study

research Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression, with Alopecia Areata in Males: A Case-Control Study

8 citations , October 2019 in “Immunological investigations”

This study suggests that the rs2075876 variant in the AIRE gene may significantly increase susceptibility to alopecia areata in the examined male population.

The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries

research The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries

46 citations , August 2019 in “Journal of the European Academy of Dermatology and Venereology”

This study found that patients with alopecia areata reported worse quality of life and higher anxiety and depression levels compared to those with androgenetic alopecia and healthy controls.

research Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety

44 citations , April 2019 in “Journal of the American Academy of Dermatology”

This study observed that cyclosporine showed a trend toward improving alopecia areata symptoms compared to placebo, but the difference was not statistically significant.

research Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study

66 citations , December 2018 in “Dermatology”

This study found that oral JAK inhibitors, ruxolitinib and tofacitinib, are effective and well-tolerated for treating severe alopecia areata, with a similar degree of hair regrowth and relapse rates, but ruxolitinib induced faster initial hair regrowth.

HRQoL in Hair Loss-Affected Patients with Alopecia Areata, Androgenetic Alopecia, and Telogen Effluvium: The Role of Personality Traits and Psychosocial Anxiety

research HRQoL in Hair Loss-Affected Patients with Alopecia Areata, Androgenetic Alopecia, and Telogen Effluvium: The Role of Personality Traits and Psychosocial Anxiety

29 citations , November 2018 in “Journal of The European Academy of Dermatology and Venereology”

This study found that anxiety-related traits significantly predict the impact of hair loss on quality of life across different alopecia types, with variations observed based on gender.

research Factors Affecting the Psychosocial Distress of Patients with Alopecia Areata: A Nationwide Study in Korea

8 citations , October 2018 in “Journal of Investigative Dermatology”

This study observed that alopecia areata patients experience significant psychosocial issues, with a high prevalence of anxiety, depression, and impaired quality of life across symptoms, functioning, and emotions.

research Comparison of Quality of Life in Patients with Androgenetic Alopecia and Alopecia Areata

23 citations , August 2018 in “Anais Brasileiros De Dermatologia”

This study found that patients with androgenetic alopecia reported more impact on their quality of life in terms of emotions, functioning, and symptoms than those with alopecia areata.

research Quality of Life with Alopecia Areata Versus Androgenetic Alopecia Assessed Using Hair Specific Skindex-29

13 citations , January 2018 in “Annals of Dermatology”

Alopecia areata and androgenetic alopecia affect quality of life similarly.

research Adaptive Regulatory Mechanisms of Alopecia Areata

3 citations , November 2017 in “PubMed”

This study found that individuals with alopecia areata experience variations in cortisol and insulin levels and adaptive mechanism pressures, which may serve as potential therapeutic targets.

research Validation of an Egyptian Arabic Version of Skindex-16 and Quality of Life Measurement in Egyptian Patients with Skin Disease

17 citations , July 2017 in “International Journal of Behavioral Medicine”

This study validated the Egyptian Arabic version of the Skindex-16 and found that skin conditions significantly impacted patients' quality of life, particularly in the emotional domain.

research Quality of Life Assessment in Patients with Alopecia Areata and Androgenetic Alopecia in the People's Republic of China

32 citations , January 2017 in “Patient Preference and Adherence”

This study found that both alopecia areata and androgenetic alopecia moderately reduced the quality of life for Chinese patients, especially in younger individuals and those experiencing hair loss for over a year.

research Illness Perception in Patients with Androgenetic Alopecia and Alopecia Areata in China

17 citations , May 2016 in “Journal of Psychosomatic Research”

This study observed that in patients with androgenetic alopecia, illness perception was linked to higher psychological distress and lower quality of life compared to those with alopecia areata.

research Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis

128 citations , February 2016 in “British Journal of Dermatology”

This study found that patients with alopecia areata experience significant impairments in health-related quality of life, notably affecting mental health, according to various quality of life assessment tools.

research Quality of Life in Patients with Alopecia Areata: A Hospital-Based Cross-Sectional Study

25 citations , December 2015 in “Journal of the European Academy of Dermatology and Venereology”

This study found that alopecia areata negatively affects patients' quality of life, though less severely than psoriasis, atopic dermatitis, and onychomycosis.

research Epidemiology and Burden of Alopecia Areata: A Systematic Review

144 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.

research Quality of Life in Alopecia Areata: A Sample of Tunisian Patients

45 citations , January 2013 in “Dermatology Research and Practice”

This study found that patients with alopecia areata experience significantly poorer quality of life compared to the general population, affecting mental health, social functioning, and overall health outcomes.

research Psychosocial Impact of Wigs or Hairpieces on Perceived Quality of Life in Female Patients with Alopecia Areata

9 citations , December 2012 in “The Journal of Dermatology”

Wearing wigs or hairpieces improves self-esteem, adaptability, and competence in women with alopecia areata.

research Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study

101 citations , January 2012 in “Annals of Dermatology”

In this study, researchers found that androgenetic alopecia significantly harms quality of life, particularly in younger patients, those with more severe or long-term alopecia, and those who have sought non-medical hair care.

research Clinical Severity Does Not Reliably Predict Quality of Life in Women With Alopecia Areata, Telogen Effluvium, or Androgenic Alopecia

86 citations , May 2011 in “Journal of The American Academy of Dermatology”

This study found that patients with alopecia perceive their hair loss as more severe than dermatologists do, and their own ratings of hair loss severity better reflect their quality of life impacts.

research Quality of Life in Alopecia Areata: A Study of 60 Cases

44 citations , August 2010 in “Journal of Investigative Dermatology”

Alopecia areata seriously lowers quality of life, especially affecting self-image, mental health, and social life.