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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Different types of skin cells play specific roles in development, healing, and cancer.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

KGF and activin are crucial for skin healing and repair.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

A genetic change in the EDAR gene causes the unique hair traits found in East Asians.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Turing patterns are now recognized as important in developmental biology.

Wnt signaling helps control how brain stem cells divide and is important for brain repair after injury.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Follistatin helps hair growth and cycling, while activin prevents it.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.