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    Glossary Wound-Induced Hair Growth

    process where skin injury stimulates new hair follicle formation

    Wound-Induced Hair Growth refers to the phenomenon where hair follicles regenerate and new hair growth is stimulated in response to skin injury. This process involves the activation of stem cells and signaling pathways that are typically dormant, leading to the repair of damaged tissue and the formation of new hair follicles. This concept is being explored for potential treatments for conditions like alopecia.

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    1. Lack of Collagen VI Promotes Wound-Induced Hair Growth Journal of Investigative Dermatology · 2015 · 32 citations
    2. 730 M2 macrophages promote wound induced hair neogenesis through the production of growth factors 2016
    3. Unwanted hair growth induced by topical epidermal growth factor during wound healing: true or myth? International Wound Journal · 2014 · 4 citations
    4. Single‐Cell Analysis of Late‐Stage Wound‐Induced Hair Follicle Neogenesis Reveals Keratinocyte Heterogeneity and Enrichment of Infundibular Basal Keratinocytes Experimental Dermatology · 2026
    5. 1469 Tissue mechanics partake in spatiotemporal patterning of wound-induced hair neogenesis in African spiny mouse Journal of Investigative Dermatology · 2018
    6. Role of collagen VI in peripheral nerves and wound-induced hair regrowth 2015
    7. M2 macrophages promote wound-induced hair neogenesis Journal of Dermatological Science · 2018 · 27 citations
    8. IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation Frontiers in Cell and Developmental Biology · 2020 · 7 citations
    9. Wound Healing Induced Hair Follicle Regeneration Stem cell biology and regenerative medicine · 2022
    10. Embryonic-like regenerative phenomenon: wound-induced hair follicle neogenesis Regenerative Medicine · 2018 · 10 citations
    11. What Do We Know About Hair Growth Induced by Wounding and Its Therapeutic Applications? Dermatologic Surgery · 2023
    12. TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells Cell Death and Disease · 2024
    13. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1–Dependent Manner Journal of Investigative Dermatology · 2018 · 36 citations
    14. Thymic stromal lymphopoietin controls hair growth Stem cell reports · 2022 · 5 citations
    15. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012 · 170 citations
    16. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling Heliyon · 2017 · 3 citations
    17. KY19382, a novel activator of Wnt/β-catenin signaling, promotes hair re-growth and hair follicle neogenesis 2020
    18. Faculty Opinions recommendation of Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    19. Faculty Opinions recommendation of Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    20. Faculty Opinions recommendation of Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    21. 1448 Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration Journal of Investigative Dermatology · 2023
    22. Wnt signaling induces epithelial differentiation during cutaneous wound healing Organogenesis · 2015 · 66 citations
    23. Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding Nature Medicine · 2013 · 237 citations
    24. Analysis the mechanism IL-36α in Wound-Induced Hair Follicle Neogenesis 2019
    25. Sex Differences in Physiological Hair Cycling and Adhesive Material-Induced Hair Regeneration in Mice bioRxiv (Cold Spring Harbor Laboratory) · 2026
    26. Adipose stem cells isolated from diabetic mice improve cutaneous wound healing in streptozotocin-induced diabetic mice Stem Cell Research & Therapy · 2020 · 29 citations
    27. 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration Biomedicines · 2022
    28. Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified Development · 1992 · 125 citations
    29. Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle‐dependent manner Experimental dermatology · 2019 · 16 citations
    30. The Identification of Bipotent Dermal Stem Cells and The Role of Anti-Inflammatory Macrophages During Hair Follicle Regeneration 2016