71 citations,
August 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Hair keratin-associated proteins are essential for strong hair, with over 80 genes showing specific patterns and variations among people.
63 citations,
April 1985 in “Journal of the American Academy of Dermatology” Topical PUVA can cause temporary hair regrowth in some alopecia areata patients but doesn't change the long-term outcome.
51 citations,
May 1984 in “Journal of the American Academy of Dermatology” Benign follicular mucinosis involves immune cells attacking hair follicles.
49 citations,
March 2014 in “Dermatologic clinics” These skin conditions in African men need combined medical treatments and lifestyle changes.
48 citations,
July 1998 in “Pediatric Dermatology” Monthly oral corticosteroid pulses effectively treat widespread alopecia areata in young patients.
34 citations,
June 2015 in “Journal of cardiovascular pharmacology and therapeutics” Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.
26 citations,
September 2013 in “Journal of Dermatological Science” Serum granulysin levels can indicate the activity and prognosis of alopecia areata.
24 citations,
November 2016 in “Cell death and disease” Skin-derived stem cells can become various cell types, including germ cell-like and oocyte-like cells.
17 citations,
February 1987 in “Journal of the American Academy of Dermatology” The hair cuticle acts as a barrier against fungal infection, which occurs only deep within the hair follicle.
17 citations,
March 1985 in “Journal of The American Academy of Dermatology” Minoxidil can lower blood pressure in some people.
16 citations,
January 1989 in “Springer eBooks” Cyproterone acetate effectively treats female hair loss by increasing healthy hair and decreasing unhealthy hair, but doesn't change hair thickness.
13 citations,
January 2012 in “Dermatology” Eruptive vellus hair cysts are rare, benign skin lesions that are hard to treat.
13 citations,
June 1999 in “Seminars in cutaneous medicine and surgery” Using topical agents before and after cosmetic surgery improves the results.
8 citations,
June 2021 in “International Journal of Molecular Sciences” Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.
7 citations,
September 1988 in “Baillière's clinical obstetrics and gynaecology” Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.
2 citations,
December 2020 in “Phytomedicine plus” Taking Saw palmetto and Pygeum africana can change the levels of certain steroids in urine, which could cause confusion in doping tests.
2 citations,
November 1987 in “Archives of Dermatology” Minoxidil solution helps regrow hair in men with hair loss, with most improvement seen at 12 months and effects lasting over 30 months.
1 citations,
March 2022 in “Journal of Dermatological Science” Adding TERT and BMI1 to certain skin cells can improve their ability to create hair follicles in mice.
November 2022 in “Journal of Investigative Dermatology” Targeting inflammation can improve scalp and hair health.
June 2021 in “Research Square (Research Square)” Statins significantly reduce testosterone and improve skin symptoms in women with PCOS.
September 2018 in “Journal of Experimental & Biomedical Sciences” DK peptides can reduce hair loss by inhibiting the 5α-reductase enzyme and have antioxidant effects.
September 2015 in “Journal watch” Triamcinolone acetonide injections help regrow hair in alopecia areata patients.
January 2013 in “Sen'i Gakkaishi” Microfibrils are key for permanent waves, and hydrolyzed keratin improves wave formation and hair condition.
January 2011 in “Yearbook of Dermatology and Dermatologic Surgery” Hair relaxers are linked to reduced cystine levels and potential hair damage.
July 1989 in “British Journal of Dermatology” Long-term use of canthaxanthin may cause reversible changes in the eye, including crystal deposits and altered vision responses.
July 1980 in “International Journal of Dermatology” Aloe vera gel is effective for treating skin conditions and is used in many cosmetic products.
June 2021 in “Reactions Weekly” Finasteride caused serious side effects and led to six suicides.
291 citations,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
266 citations,
January 2016 in “Development” The study demonstrated that YAP and TAZ proteins were crucial for skin homeostasis, particularly in the basal layer of the skin, where they were found in the nucleus and increased during wound healing. Deleting YAP and TAZ in the skin of adult mice resulted in slower cell proliferation, hair loss, and impaired wound regeneration. The nuclear localization of YAP/TAZ was regulated by Integrin-Src signaling, which was influenced by contact with the basal extracellular matrix. This mechanism was also observed in other squamous epithelia and squamous cell carcinomas. In contrast, columnar epithelia used a different mechanism involving Hippo signaling to keep YAP/TAZ in the cytoplasm. However, when columnar epithelial tumors lost their apical domain, YAP/TAZ became nuclear, making the tumors sensitive to the Src inhibitor Dasatinib.
234 citations,
November 2009 in “American journal of human genetics” Common variants in the Trichohyalin gene are linked to straight hair in Europeans.