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The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Facial feminization surgery is effective in helping transgender women appear more feminine and has high patient satisfaction.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Skin problems are very common in people with systemic lupus erythematosus and important for diagnosis.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Testosterone's muscle-building effects do not require its conversion to DHT.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.