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This chapter discusses the production, metabolism, and mechanism of action of Vitamin D, including its role in calcium and phosphate metabolism and its function in the epidermis and hair follicles, without presenting new research findings.

In this study, women treated for androgen-dependent alopecia with CPA EE2 therapy experienced significant decreases in serum vitamin B12, hemoglobin, and hematocrit levels after six months.

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

This study found no significant association between the degree of male-pattern baldness and serum 25-hydroxyvitamin D levels in healthy middle-aged and older men.

This study found that patients with myotonic dystrophy types 1 and 2 often exhibit skin abnormalities, which correlate with genotype severity and serum vitamin D levels, and suggest premature aging.

This study found that calbindin-D9k knockout mice on a maternal vitamin D-deficient and low-calcium diet developed transient alopecia, but a high-vitamin D and calcium diet in mothers reduced this effect.

This study found that feeding mice high levels of dietary vitamin A increased WNT signaling, which activated hair follicle stem cells and may have accelerated alopecia areata progression.

This study found that treatment with vitamin D increased the expression of LL-37 through the vitamin D receptor in cultured sebocytes.

This research suggests that the vitamin D receptor may regulate hair follicle cycling and provide genoprotection against skin carcinogenesis through a mechanism independent of 1,25-dihydroxyvitamin D3, based on evidence from mouse models.

A genetic mutation caused severe rickets and alopecia in an Indian patient, but high-dose calcium and phosphate treatment improved their condition.

This study demonstrated that both HR isoforms are expressed in keratinocytes, but HRDelta1072-1126 lacks corepressor activity and may act as a coactivator by inhibiting HDAC recruitment to the VDR transcriptional complex.

This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.

This study found that excess vitamin A induced stable glandular morphogenesis and mucous metaplasia in embryonic mouse vibrissa follicles, even after switching to standard medium.

This study found that women with PCOS had higher levels of Nesfatin-1 and lower levels of vitamin D, which may be linked to increased blood pressure and potential hypertension.

This study found that 1,25 dihydroxyvitamin D3 significantly increased the expression and activity of vasculoprotective natriuretic peptide receptor-A in cultured inner medullary collecting duct cells, suggesting a potential mechanistic role in cardiovascular and renal benefits.

In this study of immature male albino rats on a vitamin B12-deficient diet, vitamin B12 supplementation improved body, hair, and thymus growth more effectively than aureomycin when countering the negative effects of cortisone.

This review discusses the relationship between vitamin D and various skin diseases but reports no new clinical results, emphasizing the need to assess and correct vitamin D deficiencies.

This study found that premature hair graying is strongly associated with a family history, Vitamin B12 deficiency, and hypothyroidism, with onset as early as 5 years in patients in Gurugram, India.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.

Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.

This study found that VDR deficiency in mice leads to various skin pathologies but does not affect the phenotype or function of Langerhans cells.

This study found that a topical vitamin D3 analogue had an anti-proliferative effect on guinea pig skin epidermis.

This review discusses how vitamin D and calcium signaling are essential for wound healing by activating epidermal and hair follicle stem cells, noting that deficiencies may lead to delayed or chronic wounds.

This study found that vitamin D, ferritin, and zinc deficiencies are prevalent among patients with telogen effluvium in the greater Pittsburgh area, suggesting these should be included in initial evaluations.

This study found that female students experiencing diffuse hair fall had significantly lower Vitamin D3 levels compared to healthy controls.

In this study, dogs with sebaceous adenitis were treated with oral vitamin A, but responses varied widely, showing improvements in some cases while others experienced no benefit.

This study found that vitamin D receptor expression is associated with proliferating keratinocytes, while retinoid X receptor α is linked to differentiating keratinocytes, suggesting differential targeting by vitamin D metabolites.

This article summarizes the essential roles and effects of deficiencies of both fat-soluble and water-soluble vitamins, noting issues ranging from blindness due to vitamin A deficiency to scurvy caused by a lack of vitamin C.

This review discusses new research on the role of retinoids in skin and hair health and reports no clinical results.