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    Glossary Vitamin D Receptor

    protein that binds vitamin D to regulate gene expression

    The Vitamin D Receptor (VDR) is a protein found in various cells throughout the body that binds to vitamin D, allowing it to regulate the expression of specific genes. This receptor plays a crucial role in maintaining calcium and phosphate balance, which is essential for healthy bone formation, and it also influences immune system function and hair follicle cycling.

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    1. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocrine reviews · 2008 · 1533 citations
    2. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed Journal of bone and mineral research · 1998 · 1308 citations
    3. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice<sup>1</sup> Endocrinology · 1998 · 519 citations
    4. Vitamin D Receptor: New Assignments for an Already Busy Receptor Endocrinology · 2006 · 510 citations
    5. Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002 · 277 citations
    6. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention Nutrition reviews · 2008 · 271 citations
    7. Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling Journal of Biological Chemistry · 2003 · 215 citations
    8. Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth 2002 · 180 citations
    9. Behavioural characterization of Vitamin D receptor knockout mice Behavioural brain research · 2005 · 166 citations
    10. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis 2008 · 148 citations
    11. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004 · 144 citations
    12. Vitamin D receptor is essential for normal keratinocyte stem cell function Proceedings of the National Academy of Sciences · 2007 · 143 citations
    13. Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene 2001 · 139 citations
    14. Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands Journal of bone and mineral research · 2007 · 137 citations
    15. Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice Journal of Clinical Investigation · 2001 · 137 citations
    16. The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008 · 127 citations
    17. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998 · 119 citations
    18. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001 · 115 citations
    19. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice* Endocrinology · 2000 · 114 citations
    20. Mechanism of Vitamin D Receptor Action Annals of the New York Academy of Sciences · 2006 · 111 citations
    21. The role of vitamin D receptor mutations in the development of alopecia Molecular and Cellular Endocrinology · 2011 · 109 citations
    22. Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets BoneKEy Reports · 2014 · 107 citations
    23. Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth Endocrinology · 2003 · 104 citations
    24. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    25. Development and progression of alopecia in the vitamin D receptor null mouse Journal of cellular physiology · 2006 · 81 citations
    26. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005 · 78 citations
    27. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer The Journal of Steroid Biochemistry and Molecular Biology · 2014 · 71 citations
    28. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets due to a Mutation Causing Multiple Defects in Vitamin D Receptor Function Endocrinology · 2004 · 67 citations
    29. Quantification of the Vitamin D Receptor−Coregulator Interaction Biochemistry · 2009 · 62 citations
    30. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer Breast Cancer Research and Treatment · 2016 · 59 citations