2 citations
,
September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
2 citations
,
September 2015 in “Türk pediatri arşivi : İstanbul çocuk kliniği dergisi” This case study reports on a 23-month-old child who developed onychomadesis after valproic acid treatment, which resolved on its own without further intervention.
16 citations
,
October 1994 in “PubMed” This review, drawing on literature and personal experience, suggests that sodium valproate is a safe and effective antiepileptic drug for various epileptic conditions in children and adults, including the elderly.
July 1996 in “Annals of Internal Medicine” This correspondence reported significant variability between quantitative PCR and bDNA assays for measuring Hepatitis C virus RNA in high-titer specimens, challenging the reliability of the Chiron assay.
10 citations
,
August 2002 in “British Journal of Ophthalmology” This case study reports that intralesional cidofovir was successfully used for treatment without systemic toxicity, suggesting it might be an option worth considering for SCC.
3 citations
,
January 1985 in “British Journal of Dermatology” In this study, a low concentration zinc sulphate solution was investigated for managing recurrent herpes simplex infections, but no new clinical results were reported.
73 citations
,
January 1980 in “Annals of Neurology” This case report describes a child developing pancreatitis directly linked to valproic acid therapy.
6 citations
,
March 1986 in “PubMed” This case study describes a 19-year-old female patient who gained 13 kg and experienced hair changes while on valproic acid, and partially lost weight after reducing the dosage, but hair changes persisted.
42 citations
,
January 2019 in “Frontiers in Immunology” This study identified diltiazem, a calcium channel blocker for hypertension, as a promising repurposed treatment for influenza, enhancing antiviral efficacy when combined with oseltamivir.
44 citations
,
June 2015 in “British Journal of Pharmacology” This study found that betulinic acid inhibits hepatitis C virus replication by suppressing the NF-κB- and ERK1/2-mediated COX-2 pathway, suggesting its potential as a therapeutic supplement.
June 2025 in “Clinical Dermatology Review” This case study documents a rare concurrent presentation of herpes zoster and alopecia areata in a 24-year-old male, highlighting transient alopecia as a cutaneous complication of varicella zoster infection and suggesting further research into the virus's effect on dormant hair follicles.
5 citations
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December 2022 in “Annals Academy of Medicine Singapore” This review reports that nirmatrelvir-ritonavir has significant drug-drug interactions with many common dermatological medications, whereas molnupiravir may be an alternative therapy due to the absence of such interactions observed so far.
25 citations
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December 1995 in “Neurology” This study observed that in varicella, the varicella-zoster virus spreads to dermal endothelial cells before reaching keratinocytes, whereas in herpes zoster, it first involves cutaneous nerves and pilosebaceous units.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.
January 2017 in “SHILAP Revista de lepidopterología” Agomelatine might help reduce hair loss caused by valproate.
4 citations
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April 2007 in “Journal of Pediatric Gastroenterology and Nutrition” This case report describes a 16-year-old liver transplant patient with previous chicken pox infection experiencing disseminated varicella zoster virus infection with pneumonia, highlighting the importance of early acyclovir treatment in immunocompromised patients.
59 citations
,
October 1976 in “Acta Neurologica Scandinavica” This study found that sodium valproate significantly reduced seizure frequency by over 50% in about 70% of patients with generalized seizures but was less effective for partial seizures.
August 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies diltiazem as a promising repurposed drug for treating influenza, supported by its antiviral activity and gene modulation effects, leading to a Phase II clinical trial authorization.
42 citations
,
April 2021 in “Pharmaceuticals” This study identified five FDA-approved drugs—cepharantine, clofazimine, metergoline, imatinib, and efloxate—as potential candidates for repurposing to interfere with viral entry in COVID-19 treatment.
29 citations
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March 1987 in “Therapeutic Drug Monitoring” This study found that venous blood ammonia levels, particularly in patients taking valproate combined with other antiepileptic drugs, were significantly elevated compared to those on valproate alone.
March 2025 in “Biomedical & Pharmacology Journal” This observational study found that while 96.6% of patients using valproic acid showed the expected clinical response, over half experienced adverse reactions like weight gain, hair loss, and hepatotoxicity, highlighting the need for personalized treatment approaches to minimize these side effects.
April 2021 in “HIV & AIDS Review” This study reported that GA 0.1% spray led to only slight improvement in treating anogenital warts among HIV-positive patients over twelve weeks.
5 citations
,
November 2012 in “Journal of Clinical Psychopharmacology” This case report describes an 80-year-old man who developed valproate toxicity and functional decline after starting isoniazid, highlighting a potential drug interaction in elderly patients.
January 2025 in “Seizure” This study found that dual ASM therapies involving valproic acid were associated with poorer tolerability and specific adverse events, with cognitive side effects occurring prominently across all examined combinations.
4 citations
,
July 2019 in “Headache The Journal of Head and Face Pain” This study suggests that low alternating daily doses of sodium divalproate may be effective for migraine prevention, similarly to higher doses, but can still lead to modest weight gain.
17 citations
,
January 2011 in “The Korean Journal of Hepatology” This case report details an occurrence of Vogt-Koyanagi-Harada disease during pegylated interferon-α2b and ribavirin therapy for chronic hepatitis C.
17 citations
,
January 2008 in “Journal of the American Academy of Dermatology” Valproic acid can cause hair loss, but information on hair color change is not detailed.
4 citations
,
August 2002 in “British Journal of Ophthalmology” This study suggests that intralesional cidofovir might be a treatment option for SCC, as it showed a successful outcome without systemic toxicity in the reported case.
1 citations
,
December 1982 in “PubMed” In this study, sodium valproate as monotherapy stopped seizures in 50% of epileptic children and was most effective in primary generalized and photosensitive epilepsies with notable side effects.
3 citations
,
November 2024 in “Viruses” This study found that cepharanthine significantly inhibits EqHV-8 infection in vitro and improves lung tissue pathology in infected mice by reducing oxidative stress through specific signaling pathways, suggesting its potential as a treatment for equid herpesvirus type 8.