Protective Role of Cepharanthine Against Equid Herpesvirus Type 8 Through AMPK and Nrf2/HO-1 Pathway Activation

    November 2024 in “ Viruses ”
    Shuwen Li, Liangliang Li, Yueqi Sun … Tongtong Wang
    Studysummary This study found that cepharanthine significantly inhibits EqHV-8 infection in vitro and improves lung tissue pathology in infected mice by reducing oxidative stress through specific signaling pathways, suggesting its potential as a treatment for equid herpesvirus type 8.
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    Research cited in this study 4

    1. The Brief Overview, Antivirus and Anti-SARS-CoV-2 Activity, Quantitative Methods, and Pharmacokinetics of Cepharanthine: A Potential Small-Molecule Drug Against COVID-19 Frontiers in Pharmacology · 2023
    2. The Common Regulatory Pathway of COVID-19 and Multiple Inflammatory Diseases and the Molecular Mechanism of Cepharanthine in the Treatment of COVID-19 Frontiers in Pharmacology · 2022
    3. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021
    4. Cepharanthine: A Review of the Antiviral Potential of a Japanese-Approved Alopecia Drug in COVID-19 Pharmacological Reports · 2020