In this study, highly dynamic remodeling was observed in mouse somatosensory axons and Merkel cells, indicating that epithelial-neural interactions help maintain homeostatic remodeling, with additional intrinsic neural mechanisms contributing to axonal plasticity.
36 citations
,
January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the connection between PI3K-AKT-mTOR pathway mutations and heritable skin diseases characterized by tissue overgrowth, but it reports no new clinical results.
201 citations
,
November 1964 in “Journal of neurophysiology” The cuneate nucleus has two main neuron types: relay neurons and interneurons.
16 citations
,
February 2019 in “Pediatric Blood & Cancer” In this study, 96% of children with CNS tumors receiving MAPK and mTOR inhibitors experienced common, treatable skin reactions, occasionally requiring therapy adjustments.
3 citations
,
August 2022 in “International Journal of Molecular Sciences” This study demonstrated that 5-azacytidine treatment may reduce TSC lesion-related hair follicles in mice, suggesting chromatin remodeling agents could be effective for tuberous sclerosis cutaneous lesions lacking tuberin.
1 citations
,
September 2021 in “Pharmaceutics” In this study, finasteride was shown to inhibit glioma stem-like cells and reduce glioblastoma proliferation, suggesting its potential as an anti-glioblastoma drug.
39 citations
,
March 2022 in “Nature Protocols” This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.
25 citations
,
January 2015 in “World journal of stem cells” This review discusses the potential of hair follicle stem cells as a novel source for cell therapy in neurodegenerative disorders, but it reports no new clinical results.
228 citations
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September 2012 in “Trends in Neurosciences” This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.
November 2019 in “Neuro-oncology” This study found that using rind-based dosimetric techniques in brain irradiation significantly reduced scalp dose and alopecia compared to standard treatment plans, with 60% of patients experiencing no hair loss.
3 citations
,
October 2020 in “IntechOpen eBooks” This review discusses the potential of regenerative medicine for chronic and neuro-degenerative pain conditions and reports no new clinical results; the authors note that further trials are needed to confirm its efficacy.
January 2025 in “Nature Communications” Using synchrotron X-ray imaging, this study mapped the complex innervation of male rat vibrissa follicles, revealing distinct types of myelinated afferent neurons and patterns of axonal organization that may inform sensory processing in the brainstem.
January 2016 in “Frontiers in Neurology” This study reported that a clinical nutrition program improved sensory loss and maintained symptom improvements in a 60-year-old man with anti-MAG neuropathy over the course of one year.
21 citations
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March 2021 in “Frontiers in Neurology” This review explores how adaptive changes in cerebellar and vestibular subsystems may contribute to balance control, noting cellular mechanisms involved, but presents no new clinical findings.
January 2022 in “Exclusive Real World Evidence Journal” This case report describes a 22-year-old female with systemic lupus erythematous whose primary symptom was vasculitic polyneuropathy, characterized by polyneuropathy and various positive autoimmune markers.
February 2024 in “Rheumatology & autoimmunity” This case report documents a rare instance where homonymous hemianopia was the first manifestation of systemic lupus erythematosus in a 42-year-old woman, suggesting its potential inclusion as an initial diagnostic indicator in SLE.
3 citations
,
November 2022 in “Frontiers in molecular biosciences” This study suggests that in mice, plasmalogens may enhance hair growth by activating TRPC4 channels, which increases calcium influx and subsequently stimulates AMPK in hair follicles.
May 2022 in “Annals of the Rheumatic Diseases” This case report describes two cases of systemic lupus erythematosus (SLE) onset occurring within two months after COVID-19 vaccination, but it remains unclear if the vaccination contributed to these cases.
31 citations
,
April 2010 in “British journal of dermatology/British journal of dermatology, Supplement” This report describes two patients with frontal fibrosing alopecia who developed acute hair loss on their limbs, revealing that the limb alopecia had similar histological features to scalp alopecia.
46 citations
,
July 2007 in “Journal of comparative neurology” This study found that Florida manatees have unique types of specialized nerve endings in their vibrissae, which assist in their sensory and manipulative functions in aquatic environments.
2 citations
,
January 2018 in “European journal of pediatric surgery reports” This case report described a girl with a cervical lymphangioma whose hair texture unexpectedly changed due to Horner's syndrome following tumor resection surgery.
April 2025 in “Journal of the Association for Research in Otolaryngology” In this study, researchers observed that inhibiting myosin light chain kinase in hair cells reduced stiffness and oscillation in bullfrog hair bundles and increased hearing thresholds in mice.
September 2004 in “Experimental dermatology” This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.
65 citations
,
September 2004 in “The American journal of pathology” This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.
1 citations
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November 2025 in “Wiener Medizinische Wochenschrift” This study reports a case of fatal HHV-6 encephalitis and vasculitis in a previously healthy 49-year-old male, highlighting the occurrence of this condition even in individuals without typical risk factors, such as immunocompromised status.
This study found that Ca²⁺ signaling and peptidylarginine deiminase enzymes play a crucial role in activating neural stem cells in response to injury in zebrafish, suggesting potential therapeutic targets for CNS injuries and cancer.
November 2016 in “Elsevier eBooks” This chapter reviews genetic defects in female sexual differentiation, focusing on 46,XX disorders of sex development and the impact of genetic factors and sex steroids on development, but reports no new clinical findings.
34 citations
,
April 1973 in “The American journal of clinical nutrition” This study found that inadequate maternal pyridoxine during pregnancy led to lower body weight, slow physical development, and impaired neuromotor development in rat pups, with the severity increasing as pyridoxine levels decreased.
158 citations
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July 1993 in “The Journal of Pediatrics” This study observed that omeprazole was highly effective in reducing symptoms and esophagitis in children with severe esophagitis unresponsive to other treatments, though its long-term safety regarding elevated gastrin levels remains uncertain.
133 citations
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September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.