July 2026 in “Open Science Framework” This review identifies higher radiation doses and larger scalp exposure as major factors in radiation-induced alopecia, highlights prevention techniques like IMRT and proton therapy, and discusses management options such as minoxidil and hair transplantation, but notes limited evidence for these treatments.
19 citations
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November 2015 in “Radiation Oncology” This study found that hippocampus sparing whole brain radiation therapy (HS-WBRT) using multi-field intensity modulated radiation therapy prevents alopecia without compromising cognitive function compared to traditional whole brain radiation therapy.
June 2026 in “EJC Paediatric Oncology” In this retrospective study on pediatric craniospinal irradiation, researchers found that permanent radiation-induced alopecia occurred in 45.8% of patients, with higher radiation doses and treatment intensity being significant predictors, suggesting that defined dosimetric thresholds can support scalp-sparing planning.
May 2019 in “Journal of clinical oncology” This study found that concurrent chemotherapy with radiotherapy may increase the risk of grade 2 persistent radiation-induced alopecia, while topical minoxidil showed potential benefits, though more research is needed on its efficacy.
8 citations
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September 2015 in “Radiotherapy and oncology” This article discusses the potential for scalp cooling to prevent hair loss during radiotherapy, drawing from its efficacy in chemotherapy contexts, but it provides no new experimental results.