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research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells
Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.
research Behavior of Human Foreskin Keratinocytes Expressing a Hair Follicle Stem Cell Marker CD200
CD200 is not a reliable marker for identifying stem cells in all skin types.
research The Hair Follicle Bulge: A Niche for Adult Stem Cells
This article reviews the role of adult stem cells in tissue homeostasis and wound repair, focusing on their regulation within the murine hair follicle's specialized niche, but it presents no new findings.
research Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
research Stem cell identification-in vivo lineage analysis versus in vitro isolation and clonal expansion
This article argues that lineage labeling with genetic markers is the gold standard for identifying epithelial stem cells, contrary to the view that in vitro methods alone are sufficient.
research Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation
This study found that epithelial cell metabolism exhibits distinct heterogeneity based on cell density, particularly during the pre-epithelial transition stage where clusters of high and low mitochondrial potential cells emerge.
research 974 Single-cell analysis identifies heterogeneity of fibroblasts and myeloid-derived adipocytes in regenerating mouse skin wounds
This study found that wounding in skin induces significant fibroblast heterogeneity and recruits myeloid cells, which contribute to adipocyte regeneration in mice.
research 1378 Identification of two distinct stem cell clusters, Lrig1-derived and Wnt/CD44-dependent, in corneal epithelium
This study suggests that with aging, mouse corneal renewal increasingly relies on Lrig1+ stem cells as CD44 expression and Wnt activity decline.
research Faculty Opinions recommendation of Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.
Keratin 79 cells help form and regenerate hair canals.
research Stem cells in tissues, organoids, and cancers
This article reviews the role of stem cells in tissue development, tumor formation, and organoid generation, and highlights the potential of epigenetic regulation in advancing regenerative medicine and cancer treatment, without presenting new experimental results.
research Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells
In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.
research Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4
This study found that erythrocytes can be generated from human hair follicle mesenchymal stem cells with OCT4 expression, potentially serving as an alternative source for transfusions.
research Live-cell Imaging and Analysis of Germline Stem Cell Mitosis in Caenorhabditis elegans
This article provides a protocol for live imaging of C. elegans germline stem cells, highlighting their potential for studying mitosis and other cell processes, but does not report new experimental findings.
research Protective Effects of BCC Against Oxidative Stress in Cardiomyocyte Cells
In this study, BCC therapy reduced oxidative stress and cell damage in cardiomyocyte cells, suggesting it may serve as a new treatment alternative for heart disease.
research Global gene expression and comparison between multiple populations in the mouse epidermis
This study found that a multicolor panel of four surface markers can identify new stem cell populations in mouse hair follicles, providing insights into stem cell diversity and gene expression discrepancies during tissue culture.
research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
research Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia
Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.
research Colon Cancer Stem Cells: Promise of Targeted Therapy
This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.
research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles
In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
research Eyes open on stem cells
In this discussion, the authors highlight the murine cornea as a powerful model for stem cell research, revealing new insights into stem cell properties, differentiation flexibility, and the importance of the stem cell niche, with potential implications for understanding various tissues, diseases, and therapies.
research Diversity of Adult Stem Cell Niches in the Dermal Compartment of Skin
This review examines the diversity and role of stem cells in the adult dermis, noting a lack of precise understanding about their hierarchy and relationship to dermal fibroblast subpopulations, and reports no new results.
research Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis
This study found that epithelial cells in the skin of live mice regulate the density and spatial organization of immune cells, which actively maintain their position despite constant cell turnover.
research Lineage Analysis of Epidermal Stem Cells
Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.
research Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses
This study integrated single-cell RNA-seq data from four previous studies to create a comprehensive human corneal cell state meta-atlas, revealing novel marker genes, rare cell states, and distinct transcription factors, and offering a tool to enhance future cornea research.
research Fluorescence Activated Cell Sorting (FACS) of CK15 Cells in Canine Hair Follicular Tissue
This study found that canine hair follicle stem cells in vitro expressed markers associated with multipotency, suggesting their potential role in the hair cycle.
research The Localization of Label-Retaining Cells in Eccrine Glands
Stem cells in eccrine glands could be used for regenerative medicine.
research Small Intestinal Organoid-Derived SP Cells Contribute to Repair of Irradiation-Induced Skin Injury
This study demonstrated that stem cells from the small intestine can differentiate into skin cells and reduce skin damage in irradiated mice, supporting the theory of stem cell plasticity.
research BULGE CELLS OF RAT HAIR FOLLICLES: ISOLATION, CULTIVATION, MORPHOLOGICAL AND BIOLOGICAL FEATURES
In this study, researchers found that bulge cells cultured from rat hair follicles demonstrated stem cell characteristics and could differentiate into neural and glial lineages.
research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy
This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.