TLDR CD200 is not a reliable marker for identifying stem cells in all skin types.
The study examined the expression of the hair follicle stem cell marker CD200 in keratinocytes from 19 neonatal foreskin samples, which lack hair follicles. It was found that CD200(+) keratinocytes in foreskins did not display keratinocyte stem cell (KSC) behavior in vitro, unlike those in hair follicles. Instead, α6 integrin-bright/CD71-dim cells were more indicative of KSC in foreskin tissues. The research concluded that CD200 is not a universal marker for KSC across different skin types, emphasizing the need for additional markers to accurately identify KSC for regenerative medicine applications.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
550 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
1279 citations
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November 2005 in “Nature Medicine” 233 citations
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October 2004 in “Differentiation” Stem cells are in deep skin layers, while differentiating cells are in shallow layers.
24 citations
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November 2013 in “Trends in pharmacological sciences” Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.
236 citations
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
10 citations
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94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
