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    Glossary Type I Keratin

    Type I keratin is a fibrous protein that is a key structural component of hair, skin, and nails. It is classified as an acidic keratin and is primarily found in the hard tissues of the body, contributing to the strength and resilience of hair strands. In the context of hair loss, understanding type I keratin is relevant as it plays a crucial role in hair follicle health and integrity; any disruption in its production or structure can lead to weakened hair and increased susceptibility to hair loss. Distinguishing characteristics of type I keratin include its high tensile strength and its ability to form complex structures with other keratins, particularly type II keratins, to create the overall architecture of hair.

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    1. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix Human Genetics · 1997 · 100 citations
    2. Type II Keratins Are Phosphorylated on a Unique Motif during Stress and Mitosis in Tissues and Cultured Cells Molecular Biology of the Cell · 2002 · 80 citations
    3. Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007 · 70 citations
    4. The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain Differentiation · 2004 · 70 citations
    5. Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues. Journal of Biological Chemistry · 1987 · 57 citations
    6. A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13 Human Molecular Genetics · 1995 · 54 citations
    7. Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes Experimental Cell Research · 1995 · 52 citations
    8. A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11 Genomics · 1989 · 49 citations
    9. Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3 Experimental Cell Research · 1994 · 47 citations
    10. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion 2011 · 30 citations
    11. A homozygous missense variant in type I keratin <i>KRT25</i> causes autosomal recessive woolly hair Journal of Medical Genetics · 2015 · 29 citations
    12. A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform Journal of Biological Chemistry · 1997 · 28 citations
    13. Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity British Journal of Dermatology · 1997 · 21 citations
    14. <i>In vitro</i> Assembly Properties of Human Type I and II Hair Keratins Cell structure and function · 2014 · 12 citations
    15. The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets? 2005 · 9 citations
    16. Seasonal Variability in Transcript Expression of Type I and Type II Keratins in Wool Follicles of Lustrous Fleece-Producing Magra Sheep Journal of Natural Fibers · 2023 · 1 citations
    17. A group of type I keratin genes on human chromosome 17: characterization and expression. Molecular and Cellular Biology · 1988 · 141 citations
    18. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    19. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    20. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988 · 38 citations
    21. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    22. Complete sequence of a hair-like intermediate filament type II keratin gene DNA sequence · 1993 · 15 citations
    23. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    24. A missense mutation in the type II hair keratin hHb3 is associated with monilethrix Journal of Medical Genetics · 2005 · 79 citations
    25. Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain Journal of Investigative Dermatology · 2000 · 77 citations
    26. Sequences and differential expression of three novel human type-II hair keratins Differentiation · 1997 · 61 citations
    27. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003 · 60 citations
    28. A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type Journal of Medical Genetics · 2006 · 60 citations
    29. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004 · 49 citations
    30. A Variable Monilethrix Phenotype Associated With a Novel Mutation, Glu402Lys, in the Helix Termination Motif of the Type II Hair Keratin hHb1 Journal of Investigative Dermatology · 1998 · 47 citations