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The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Food intake, not genetics, affects how the body processes tadalafil and finasteride.

Hesperidin helps protect against testicular damage caused by finasteride.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.

Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Higher DHT in male baldness may protect against prostate cancer.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

DHT stops hair regrowth in mice, similar to human hair loss.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

Ginsenoside F2 may help prevent hair loss and promote hair growth better than finasteride.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Treat hair loss with finasteride, minoxidil, or surgery; consider side effects and severity.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

Gene mutations can cause problems in male genital development.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Two drugs, finasteride and minoxidil, are approved for hair loss treatment, but new therapies are being developed.

Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.