20 citations,
June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.
35 citations,
October 2004 in “Biology of Reproduction” PNU157706 reduced rat sperm movement and fertility without affecting offspring health.
14 citations,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.
59 citations,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.
124 citations,
March 2012 in “JAMA” Testosterone's muscle-building effects do not require its conversion to DHT.
Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.
93 citations,
January 1996 in “Clinical Pharmacokinectics” Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.
36 citations,
October 2009 in “Journal of Investigative Dermatology” Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
1 citations,
November 2023 in “Biomedicines” Menopause can cause hair thinning and texture changes due to hormonal and metabolic shifts.
8 citations,
July 2014 in “General and Comparative Endocrinology” Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
3 citations,
October 2020 in “Bladder cancer” 5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.
37 citations,
October 2014 in “Maturitas” Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.
11 citations,
August 1997 in “Expert Opinion on Therapeutic Patents” Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.
581 citations,
October 1998 in “Journal of The American Academy of Dermatology” Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
March 2000 in “The Journal of pharmacy technology” Finasteride effectively treats mild to moderate hair loss in men aged 18-41, with some side effects.
1 citations,
October 2018 in “InTech eBooks” Ethosomes are a promising method for treating hair loss by delivering drugs directly to the scalp.
2 citations,
March 2018 in “Current Opinion in Urology” 5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.
31 citations,
September 2008 in “International Journal of Andrology” 5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.
39 citations,
August 2004 in “International journal of gynaecology and obstetrics” Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.
195 citations,
February 2007 in “The Journal of Clinical Endocrinology and Metabolism” Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
47 citations,
August 2000 in “Endocrine Reviews” The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.
33 citations,
September 2017 in “Molecules” Red ginseng oil and its components help promote hair regrowth and could treat hair loss.
23 citations,
July 1993 in “Pharmacotherapy” Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.
63 citations,
August 2008 in “Journal of Cosmetic Dermatology” Cuscuta reflexa extract may help treat hair loss caused by hormones.
8 citations,
September 2008 in “Medical Hypotheses” The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.
11 citations,
January 2015 in “Current problems in dermatology” The conclusion is that treatments like finasteride and minoxidil can prevent baldness progression and improve hair density, but more research is needed on other therapies.
229 citations,
August 2002 in “Experimental Gerontology” AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
136 citations,
March 1996 in “Journal of the American Chemical Society” Finasteride effectively blocks enzyme causing male pattern baldness.
July 2023 in “International journal of life science and pharma research” The herbal hair cream could help treat male pattern baldness by blocking a baldness-related enzyme and might be worth further investigation.
30 citations,
December 2017 in “Medical Hypotheses” The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.