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5-alpha reductase inhibitors, like finasteride and dutasteride, are used for prostate issues, hair loss, and excessive hair growth, may help with COVID-19, but can cause sexual and mental health side effects, and their use in preventing prostate cancer needs more examination.

Finasteride helps treat hair loss by blocking enzyme activity.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

Solanum nigrum may help treat hair loss.

Minoxidil 2% is more effective for female hair loss, but botanicals have fewer side effects.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Taking both finasteride and dutasteride for prostate issues may raise the risk of heart problems.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

The new particle system could be a promising treatment for diseases related to the 5-α reductase enzyme.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Some vegetables from Northern Thailand show promise for health benefits, including hair loss treatment and antioxidant properties.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

A herbal extract may help treat certain types of hair loss by reducing a specific gene's activity.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Testosterone's muscle-building effects do not require its conversion to DHT.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.