October 2025 in “Interdiciplinary Journal and Hummanity (INJURITY)” This study characterized bioactive compounds in extracts from six Kalimantan herbal plants, confirming traditional medicinal uses with findings such as triterpenoids and several potent compounds with antimicrobial and cardiovascular benefits, laying groundwork for potential therapeutic applications and conservation efforts.
76 citations
,
February 2015 in “Industrial Crops and Products” This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
7 citations
,
January 2017 in “Biological & Pharmaceutical Bulletin” This study found that polyacetylene compounds in Panax ginseng extracts may inhibit neurotrophin receptor binding, suggesting potential therapeutic benefits for alopecia and other hair growth disorders.
In this study, researchers identified an elite germplasm of the medicinal plant Eclipta alba, known for its liver disease benefits, with higher growth, yield, and wedelolactone content, suitable for large-scale cultivation to reduce strain on wild populations.
January 2025 in “Institutional Repositories DataBase (IRDB)” This study observed that topical application of maslinic acid stimulated hair growth in mice comparably to minoxidil, possibly through the Wnt/β-catenin pathway and involving ciliary gene activity, highlighting increased levels of trichogenic gene expression and protein levels.
61 citations
,
April 2014 in “Radiation Research” This study observed that topically applied RTA 408 reduced the severity of radiation-induced dermatitis in mice, with the highest dose significantly reducing and alleviating skin damage and associated inflammation.
17 citations
,
August 2012 in “Archives of Pharmacal Research” Acankoreoside J from Acanthopanax koreanum may help promote hair growth.
10 citations
,
August 2024 in “Clinical Cosmetic and Investigational Dermatology” This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.
8 citations
,
April 2020 in “Journal of Ethnopharmacology” This review assessed experimental studies on herbs used for alopecia, identifying potential mechanisms involving hair cycle management and keratinocyte processes, but highlighted a need for improved evidence on quality control and toxicity of these herbal treatments.
11 citations
,
February 2021 in “Trends in Food Science and Technology” This review explores the potential of edible flowers, particularly the genus Impatiens, for their chemical, nutritional, and bioactive properties but does not report new clinical findings.
June 2024 in “Okayama University Scientific Achievement Repository (Okayama University)” In this study, methanol extracts from Thai-colored rice fermented with Aspergillus molds exhibited an increase in polyphenolic content and antioxidant activity, outperforming Thai white and Japanese white rice, notably transforming key polyphenols like quercetin and ferulic acid.
July 2026 in “Discover Food” This review critically examines scientific evidence on the health benefits of rosemary bioactives, finding potential in managing age-related diseases and skin aging conditions, and discusses their application in functional foods and aromatherapy, along with associated safety concerns.
1 citations
,
February 2024 in “Preprints.org” This review discusses the pharmacology and potential therapeutic effects of rare ginsenoside compound K on metabolic disorders but presents no new clinical results, highlighting the need for further studies on its bioavailability and toxicity.
This review reports that extracts from the plant Eclipta alba, traditionally used in herbal medicine, may promote hair growth by inhibiting TGF-β1 expression and functioning as a 5α-reductase inhibitor, potentially benefiting androgenic alopecia treatment.
2 citations
,
January 2020 in “Journal of Pharmacognosy and Phytochemistry” This article reviews the medicinal significance of the Eclipta alba plant in India and its therapeutic properties, but reports no new clinical results.
July 2025 in “ACS Pharmacology & Translational Science” In this study, maslinic acid applied topically was observed to stimulate hair growth in mice comparably to minoxidil, primarily activating pathways like Wnt/β-catenin, and suggesting a link between hair growth and cilia activity.
8 citations
,
November 2023 in “Frontiers in Bioengineering and Biotechnology” This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.
17 citations
,
September 2024 in “Cosmetics” This study assessed the antioxidant properties and contents of carotenoids and chlorophylls in 10 plant oils, finding fenugreek seed oil to be highest in carotenoids and pomegranate oil most active against free radicals, highlighting their potential as natural materials with antioxidant benefits.
15 citations
,
April 2022 in “Biointerface Research in Applied Chemistry” This review presents current evidence on medicinal plants and their phytoconstituents, such as phenolic compounds, used in acne treatment, highlighting their potential as alternatives to conventional therapies due to issues like antibiotic resistance and high cost.
11 citations
,
March 2024 in “Current Issues in Molecular Biology” This review discusses the pharmacological actions and potential therapeutic benefits of ginsenoside compound K for metabolic disorders, reports no new clinical results, and suggests further research on its bioavailability and toxicity.
January 2025 in “Journal of Pharmacognosy and Phytochemistry” This review highlights the potential of marine-derived nutraceuticals for treating skin and hair disorders, focusing on Viviscal, a supplement shown to be safe and effective in enhancing hair growth by improving cellular function and strengthening hair.
December 2024 in “Revista Brasileira de Plantas Medicinais” This study reviewed in vivo studies and clinical trials on phenolic compounds, like tannins and flavonoids, for treating hair loss, noting their antioxidant and anti-inflammatory effects but highlighting the need for more clinical trials to confirm benefits.
July 2024 in “Annals of Phytomedicine An International Journal” In this study, the authors reviewed various herbal ingredients used in hair care products and found that components like aloe vera, hibiscus, amla, and fenugreek have traditional and scientifically validated benefits for addressing hair issues such as hair loss, dandruff, and damage.
This review examines natural bioactive compounds for their potential to alleviate androgenetic alopecia, emphasizing compounds like ginseng and curcumin, but reports no new experimental results.
This review highlights the potential of plant-derived natural compounds as biocompatible and biodegradable materials in dermal and transdermal delivery systems, emphasizing their unexplored benefits and detailing recent advances in isolation techniques and drug delivery technologies.
January 2020 in “Elsevier eBooks” This chapter provides an overview of phytochemicals with properties to combat alopecia and discusses the potential of flavonoids, found in several herbs, as a safer alternative to synthetic hair loss treatments due to their long-term skin compatibility.
December 2025 in “Journal of Nanobiotechnology” This study introduced a novel microneedle-based system for androgenetic alopecia treatment, which delivered Ginsenoside Compound K and S-nitrosoglutathione to enhance hair regeneration by improving the hair follicle microenvironment and promoting follicular cell proliferation.
11 citations
,
August 1997 in “Expert Opinion on Therapeutic Patents” This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
188 citations
,
December 2020 in “Foods” This review explores the potential health benefits of food bioactive compounds, specifically polyphenols, as preventive agents against non-communicable diseases like cancer and cardiovascular disorders, while also addressing challenges like bioavailability and industrial applications.
November 2023 in “Plants” This study evaluated compounds from Jatropha cordata bark, finding that a sterol mixture and n-heptyl ferulate demonstrated notable anti-inflammatory activity in murine macrophage cells without toxicity, suggesting potential for treating chronic inflammation.