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Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Treatments for melanin disorders exist, but more effective options needed.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

Female pattern hair loss can be treated with medications, surgery, and cosmetic products, considering its psychological impact.

Minoxidil effectively treats severe hypertension, but watch for side effects.

Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.

Women with PCOS have higher androgen levels that decrease with age but are still higher than in women without PCOS.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Blue light promotes hair growth by interacting with specific receptors in hair follicles.

Bald men are often viewed more negatively and as older than they really are.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.

Msx2 and Foxn1 are both crucial for hair growth and health.

Most low-level light therapy studies did not accurately report how light was measured, affecting treatment reliability.

Minoxidil use increases facial hair growth in females, more in older users.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Minoxidil improves blood flow in heart failure patients.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

Key genes are crucial for Drosophila wing development and could be insecticide targets.

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.