December 2020 in “Journal of Face Aesthetics” This study found that trichoscopy, a non-invasive diagnostic method, may effectively differentiate between types of focal alopecia in the parietal area in adult women, indicating specific trichoscopic features for conditions like alopecia areata, discoid lupus erythematosus, and lichen planopilaris.
1 citations
,
July 2020 in “Benha Journal of Applied Sciences” This study identified that trichoscopy can effectively diagnose frontal fibrosing alopecia by highlighting specific scalp abnormalities in postmenopausal women.
81 citations
,
August 1979 in “Archives of Dermatology” This case report describes a trichofolliculoma with perineural invasion, highlighting a rare and clinically significant finding in a typically benign hair follicle tumor.
35 citations
,
March 2010 in “British journal of dermatology/British journal of dermatology, Supplement” This study demonstrates that mouse eyelashes can effectively model human eyelash growth to analyze morphology, development, and the effects of growth-stimulatory agents like bimatoprost.
24 citations
,
December 1957 in “Experimental Cell Research” This study observed that the glassy layer of hair follicles in guinea pigs consists of thick collagen-type fibrils organized into two distinct arrays, whereas in young mice, the fibrils are thinner and develop between the outer root sheath and fibroblasts.
May 2020 in “JOJ Dermatology & Cosmetics” This report describes a rare case of Trichostasis Spinulosa on the heel, an uncommon location for this type of lesion.
72 citations
,
July 1984 in “Journal of Investigative Dermatology”
29 citations
,
March 2008 in “Dermatologic Surgery” This study developed a prototype device that suggests potential for diagnosing changes in hair quantity, diameter, and density, though formal clinical studies are needed to confirm these findings.
December 2015 in “Vascular Pharmacology” Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.
November 2025 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin” This study examined 16 sporadic trichoblastic tumors and found that although one showed malignant transformation, clinical follow-up revealed no residual or metastatic disease. RNA sequencing indicated a high tumor mutational burden and absence of a UV-related signature, helping to distinguish these tumors from similar growths.
November 2024 in “Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University” This study concluded that trichoscopy is an effective, non-invasive tool for diagnosing telogen effluvium, with significant differences in trichoscopic findings between frontal and occipital scalp regions, aiding in distinguishing it from androgenetic alopecia for early diagnosis.
48 citations
,
July 1993 in “Archives of Dermatological Research” Merkel cells are abundant in facial vellus hair follicles, especially during the anagen phase.
1 citations
,
January 2020 in “Indian Dermatology Online Journal” This article reviews the Directory of Open Access Journals, an extensive global index of quality open access journals, and reports no new results.
479 citations
,
January 2005 in “BioEssays” This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.
224 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
209 citations
,
September 2008 in “Dermatologic Therapy” This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.
199 citations
,
April 2010 in “Nature” A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
165 citations
,
August 2013 in “Lasers in Surgery and Medicine” This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.
165 citations
,
June 2007 in “European Journal of Cell Biology” This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.
160 citations
,
January 2009 in “Clinical Drug Investigation” This study found that the HairMax LaserComb® significantly increased hair density and was safe and well tolerated for treating androgenetic alopecia in men compared to a sham device.
130 citations
,
August 2015 in “Experimental Dermatology” This review provides a comprehensive guide to serum-free human hair follicle organ culture methods, highlighting research opportunities, standardization efforts, and potential applications without reporting new empirical findings.
109 citations
,
December 1998 in “The Journal of Dermatology” This review discusses the hair follicle cycle's complex regulation and highlights the potential for targeting catagen control in future therapies without presenting new experimental data.
100 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.
98 citations
,
February 2007 in “Seminars in Cell & Developmental Biology” This review explores the hormonal regulation of hair growth and changes with season, age, and sexual development, and calls for improved treatments for hair disorders.
89 citations
,
September 2010 in “Annual Review of Genomics and Human Genetics” This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.
87 citations
,
July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that beard hair medulla cells express an unexpected range of keratins, showing variability and promiscuous behavior in keratin interactions distinct from other hair follicle cells.
86 citations
,
October 2005 in “Experimental Dermatology” This review explores the role of Foxn1 in mammalian skin biology, discussing its influence on hair follicle function and the potential for further research to enhance understanding of epithelial differentiation.
81 citations
,
July 2011 in “Lasers in Medical Science” This study found that using a low-level laser comb led to hair regrowth in a mouse model of alopecia areata, while sham-treated mice showed no hair regrowth.
66 citations
,
July 2015 in “Journal of Molecular Biology” This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.
64 citations
,
January 2010 in “The FASEB Journal” This study found that prolactin is a key regulator of keratin expression in human hair follicles, enhancing specific keratin types and influencing epithelial stem cell-associated keratins.