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This study found that testosterone and finasteride were significantly associated with reports of male-factor infertility based on FDA pharmacovigilance data from 2010 to 2020.

This study used molecular docking to identify stiripentol as a potential new inhibitor of the SRD5A2 enzyme, which is targeted for treating androgen-related diseases; however, in vivo trials are needed to validate its efficacy.

In this study, Allium macrostemon Bunge extract was found to promote hair regrowth in a testosterone-induced androgenetic alopecia mouse model by activating Wnt/β-catenin signaling and boosting hair dermal papilla cell proliferation and growth factor expression.

This study found that disrupting testosterone biosynthesis in male rats mitigated cardiovascular and autonomic impairments caused by endotoxemia, indicating testosterone's significant role in these conditions.

Baricitinib effectively promotes beard regrowth in most men with alopecia areata universalis.

This study found that extracts from the plant Platycodon grandiflorum, particularly the butanol extract, demonstrated potential in preventing hair loss by showing significant antioxidant activity, promoting cell proliferation, and inhibiting inflammation in various cell models.

This case study potentially links the use of anabolic steroids to increased severity of COVID-19 in a healthy 28-year-old man, with marked symptom improvement following treatment with proxalutamide.

This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.

In this study, osthenol was identified as a highly potent inhibitor of 5alpha-reductase type I in LNCaP cells, significantly outperforming finasteride.

This review outlines the major health consequences of anabolic-androgenic steroid abuse, with a focus on sexual and reproductive issues, and suggests management prioritizes cessation and relapse prevention due to lack of robust randomized trials.

This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.

This research review examined existing studies on the medicinal properties of Tridax procumbens and found that its secondary metabolites have potential for treating various ailments, especially in tropical regions, though more studies are needed to fully understand its potential applications and safety.

The researchers reported that epitestosterone treatment reduced eicosanoid levels generated by cyclooxygenases and lipoxygenases in rabbit liver samples with carrageenan-induced inflammation.

This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.

In this study using a macaque model, RU58841 at a 5% concentration significantly increased hair density, thickness, and length in the frontal bald scalp over six months.

This review highlights that Fenugreek seeds and leaves contain different bioactive compounds, with seeds showing anti-diabetic and anti-hyperlipidemic effects and leaves exhibiting strong anti-microbial properties. Both parts also provide anti-inflammatory benefits and support hair health, underscoring the potential for optimized therapeutic applications from Trigonella foenum-graecum.

This abstract discusses treatment options for benign prostatic hyperplasia and provides no new clinical results.

This review explores the potential benefits of using medicinal plants as an alternative or supplementary therapy for improving reproductive and metabolic health in women with polycystic ovary syndrome, but reports no new results.

This study found that Ganoderma lucidum extracts showed weak 5alpha-reductase inhibition but significantly inhibited prostate cell proliferation and testosterone-driven prostate growth in rats, suggesting potential as an ingredient for treating androgen-induced diseases.

This review explores plant-derived phytochemicals, such as phytosterols, polyphenols, and fatty acids, for their potential use as alternative treatments for prostate cancer, emphasizing their effects on 5-alpha-Reductase enzyme isozymes. It reports no new clinical results.

This study found that a combination of 5% hexane extract of Curcuma aeruginosa and 5% minoxidil slowed hair loss and increased hair growth in men with androgenetic alopecia.

This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.

This study suggests that antiandrogens may slightly reduce hirsutism severity compared to placebo, but evidence is weak and their relative efficacy remains uncertain.

This study found that Sonic Hedgehog protein treatment enhanced the sprouting and regeneration of pelvic ganglia and cavernous nerves after injury, with localization of delivery affecting outcomes.

This study found that a blackcurrant extract with phytoestrogen activity increased hair number and stem cell marker expression in a menopausal rat model, suggesting a potential benefit for hair loss.