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New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

A woman was the first known case to have both polycystic ovary syndrome and autoimmune polyglandular syndrome type 2, suggesting a need to check for both conditions in similar patients.

Early over-expression of FoxN1 harms immune and skin development.

Women with myotonic dystrophy might get diseases related to male hormones because their body tissues are extra sensitive to these hormones.

Chemotherapy and radiotherapy can cause skin side effects like rashes, hair loss, and nail changes, which are usually managed with conservative treatments.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Combining Traditional Chinese Medicine and Western medicine can improve symptoms, hormone levels, and pregnancy outcomes in Polycystic Ovary Syndrome patients, but more research is needed.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Stress can worsen skin conditions by affecting hormone levels and immune response.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Treatments for hair loss include estrogen therapy and special shampoos.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.