TLDR Women with myotonic dystrophy might get diseases related to male hormones because their body tissues are extra sensitive to these hormones.
The document describes three cases where females with myotonic dystrophy, a condition typically associated with lower serum androgen levels compared to normal controls, developed androgen-dependent diseases such as acne, hidradenitis suppurativa, androgenetic alopecia, and keratosis pilaris. These cases suggest that the sensitivity of body tissues to androgens, rather than the absolute levels of circulating androgens, plays a significant role in the development of androgen-dependent conditions.
50 citations,
December 1999 in “British Journal of Dermatology” Finasteride improves hidradenitis suppurativa but not for child-bearing women.
December 2021 in “Acta Marisiensis” Insulin resistance increases the risk of developing type 2 diabetes and other health issues.
12 citations,
June 2016 in “Reviews in Endocrine and Metabolic Disorders” Some skin diseases and their treatments can negatively affect male fertility.
September 2022 in “Dermatology and therapy” Androgenetic alopecia is linked to heart disease, metabolic issues, and mental health problems.
186 citations,
July 1998 in “Journal of Cutaneous Medicine and Surgery” Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.
53 citations,
January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Reduced AR gene methylation may cause early pubic hair growth in girls.
