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GlossaryTime-of-Flight Secondary Ion Mass Spectrometry

analytical technique identifying surface composition by measuring ejected ions' flight time

Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is an analytical technique used to identify the composition of surfaces at a microscopic level. It works by bombarding a sample with a focused beam of ions, causing secondary ions to be ejected from the surface. These ejected ions are then measured based on their time of flight, which allows for the determination of their mass and, consequently, the identification of the elements and molecules present on the surface. This method is highly sensitive and can provide detailed chemical information about the outermost layers of a material.

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research Mapping Penetration of Cosmetic Compounds into Hair Fibers Using Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)

3 citations, September 2005 in “International Journal of Cosmetic Science”

Different oils penetrate hair differently; monounsaturated oils like olive oil penetrate better than polyunsaturated oils.

research Structural Analysis of the Outermost Hair Surface Using TOF-SIMS with Gas Cluster Ion Beam Sputtering

11 citations, January 2016 in “Biointerphases”

The hair's outermost surface has multiple layers of lipids and proteins.

research ToF-SIMS Characterization of the Lipid Layer on the Hair Surface: The Damage Caused by Chemical Treatments and UV Radiation

23 citations, May 2010 in “Surface and interface analysis”

Chemical treatments and UV radiation severely damage the lipid layer on hair.

research Investigation of Human Hair Using ToF-SIMS: From Structural Analysis to the Identification of Cosmetic Residues

4 citations, April 2018 in “Journal of vacuum science and technology. B, Nanotechnology & microelectronics”

The conclusion is that a new method can identify cosmetic residues on hair and match them to their products.

research Penetration of Cationic Conditioning Compounds into Hair Fibers: A TOF-SIMS Approach

2 citations, January 2006 in “International Journal of Cosmetic Science”

The study found that certain conditioning compounds can penetrate hair and potentially improve its resistance to damage.

research Biomimetics Through Bioconjugation of 16-Methylheptadecanoic Acid to Damaged Hair for Hair Barrier Recovery

April 2024 in “Research Square (Research Square)”

16-MHA can restore the barrier and moisture of damaged hair, making it similar to undamaged hair.

research Novel Insights Into Ascorbic Acid Skin Permeation

July 2020

The best way to apply vitamin C to the skin is with a nanostructured lipid carrier formulation.

research Investigation of the Damage on the Outermost Hair Surface Using ToF-SIMS and XPS

25 citations, December 2011 in “Surface and interface analysis”

Bleaching hair causes significant damage by breaking down proteins and fatty acids.

research Dyeing Regions of Oxidative Hair Dyes in Human Hair Investigated by Nanoscale Secondary Ion Mass Spectrometry

25 citations, January 2013 in “Colloids and surfaces. B, Biointerfaces”

Hair dye colors mainly target melanin granules in black hair.

research Distribution of Glycolipid and Unsaturated Fatty Acids in Human Hair

18 citations, August 2014 in “Lipids”

Human hair has more unsaturated fats inside than on the surface, and certain lipids may help bind the outer and inner layers together.

Extractives of Cercidiphyllum Japonicum Twigs: Isolation and Structural Elucidation of a New Galloylflavonol Glycoside, Anomeric Tannins and Flavonoids

research Extractives of Cercidiphyllum Japonicum Twigs: Isolation and Structural Elucidation of a New Galloylflavonol Glycoside, Anomeric Tannins and Flavonoids

3 citations, April 2018 in “Holzforschung”

Scientists found a new natural compound and other known compounds in Cercidiphyllum japonicum twigs, which might be useful for medicine.

research A Review on Forensic Toxicological Analysis of Drugs in Hair Using Various Instrumental Techniques

1 citations, January 2023 in “International journal of all research education and scientific methods”

Hair analysis is better than urine and blood for detecting past drug use.

research Structure of Intermediate Filament Assembly in Hair Deduced from Hydration Studies Using Small-Angle Neutron Scattering

9 citations, April 2019 in “Journal of structural biology”

Hair's internal fibers are arranged in a pattern that doesn't let much water in, and treatments like oils and heat change how much water hair can absorb.

Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1

research Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1

November 2022

Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.

research Distribution Analysis of Triglyceride Having Repair Effect on Damaged Human Hair by TOF-SIMS

8 citations, January 2012 in “International journal of polymer analysis and characterization/IJPAC. International journal of polymer analysis and characterization/IJPAC. International journal of analysis and characterization”

Hydrogenated palm oil repairs and conditions damaged hair by preventing swelling.

research Impact of Hair Damage on the Penetration Profile of Coconut, Avocado, and Argan Oils into Caucasian Hair Fibers

April 2024 in “Cosmetics”

Different oils affect hair flexibility and strength, with their impact varying on whether hair is virgin or bleached.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

research Degradation of Hair Surface: Importance of 18-MEA and Epicuticle

25 citations, May 2019 in “Cosmetics”

18-MEA and cationic surfactants can restore and maintain hair's hydrophobic nature, improving its beauty and feel.

research The Impact of AP Collagen Peptides on Hair Shaft Elasticity and Gloss: A Comprehensive Analysis

November 2024 in “Journal of Functional Foods”

AP collagen peptides improve hair elasticity and gloss.

research Hair After Death

16 citations, January 2010 in “Springer eBooks”

Secondary Ion Mass Spectrometric Investigation of Penetration of Coconut and Mineral Oils into Human Hair Fibers: Relevance to Hair Damage

research Secondary Ion Mass Spectrometric Investigation of Penetration of Coconut and Mineral Oils into Human Hair Fibers: Relevance to Hair Damage

11 citations, June 2001 in “PubMed”

Coconut oil can penetrate hair better than mineral oil, potentially protecting against damage.

research Improved Forensic Hair Evidence for Drugs of Abuse by Mass Spectrometry

June 2016

Forensic hair analysis for drugs is now more reliable and accurate.

research High Resolution Full Scan Liquid Chromatography Mass Spectrometry Comprehensive Screening in Sports Antidoping Urine Analysis

49 citations, December 2017 in “Journal of pharmaceutical and biomedical analysis”

The method effectively detects banned substances in urine for sports antidoping.

research Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex

21 citations, October 2011 in “PloS one”

Certain molecules in hair change with age and could be used for cosmetic treatments.

research Medicinal and Edible Plant Allium Macrostemon Bunge for the Treatment of Testosterone-Induced Androgenetic Alopecia in Mice

May 2023 in “Journal of Ethnopharmacology”

The wild garlic plant, Allium macrostemon Bunge, can promote hair growth and could potentially be used to treat hair loss.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations, March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

research Water Extract of Cacumen Platycladi Promotes Hair Growth Through the Akt/GSK3β/β-Catenin Signaling Pathway

February 2023 in “Frontiers in Pharmacology”

Water extract of Cacumen Platycladi helps hair growth by activating specific cell pathways.

research Advances and Challenges in Plant Sterol Research: Fundamentals, Analysis, Applications and Production

1 citations, September 2023 in “Molecules (Basel. Online)”

Plant sterols have health benefits like lowering cholesterol, but more research is needed to understand their effects and improve their extraction and sustainability.

research Simultaneous Determination of 30 Hormones Illegally Added to Anti-Aging Functional Foods Using UPLC-MS/MS Coupled with SPE Clean-Up

6 citations, September 2014 in “Food Additives & Contaminants: Part A”

New method effectively detects illegal hormones in anti-aging foods.

research Metal Chelation Assisted Deposition of Polydopamine on Human Hair: A Ready-to-Use Eumelanin-Based Hair Dyeing Methodology

63 citations, February 2017 in “ACS biomaterials science & engineering”

Polydopamine is a safe, effective, and permanent hair dye that turns gray hair black in one hour.