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RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

A woman with Cushing's syndrome improved after surgery to remove a tumor causing the condition.

The skin and thymus develop similarly to protect and support immunity.

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

The document concludes that parathyroid diseases have a range of clinical features and outcomes, with some conditions being treatable and others having a high risk of mortality.

TSLP affects atopic dermatitis by increasing sebum and reducing fat through IL-4/IL-13 signaling.

Genetic screening is crucial for accurately diagnosing APS-1 due to its varied symptoms.

The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.

Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

A cat with a rare pancreatic tumor and diabetes died despite treatment, showing similar symptoms to a human condition.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Targeting immune tolerance issues in Alopecia Areata could restore hair growth and maintain remission.

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

Dog skin with hair loss, when transplanted to mice, regrew hair, suggesting the hair loss cause is likely body-wide, not skin-specific.

WNT10B is linked to cancer development and affects survival and disease progression in various cancers.

The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Cathepsin L is essential for normal hair growth and development.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Thymus transplantation successfully restored immune function in infants with FOXN1 deficiency.

Mutant mice help researchers understand hair growth and related genetic factors.