Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.

Hormonal contraceptives and related compounds can increase health risks like thrombosis and affect sexual function.

This case study describes a rare steroid cell tumor of the ovary in a 42-year-old woman, highlighting its virilizing effects and the importance of thorough follow-up due to its potential for malignancy.

This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.

This study describes molecular mechanisms explaining how sex and stress steroids rapidly modulate dendritic spine formation in hippocampal neurons, suggesting recovery-like effects under steroid-depleted conditions compared to intact conditions.

This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.

This article discusses the complex interaction between androgens and the skin, highlighting elevated androgen levels in women with hirsutism, female-pattern hair loss, and acne, but reports no new clinical results.

Post-steroid panniculitis is now rare because doctors taper steroids more carefully.

This case report observed hypertrichosis on the left forearm of an 80-year-old woman, possibly linked to her previous use of the topical steroid betamethasone butyrate propionate for dermatitis.

In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.

This review discusses the diagnosis, management, and hormone treatment of transsexual individuals, and examines the risks and effects of cross-sex hormone therapy without presenting new clinical results.

This study found that thiol disulfide homeostasis is balanced in male patients with androgenetic alopecia, though oxidative stress may be more prominent with emotional stress and vitamin D deficiency.

This article hypothesizes that thymoma with aplastic anemia may result from abnormal autoimmune CD8⁺ T lymphocytes produced by the thymoma, potentially leading to other cytotoxic T-cell-mediated autoimmune diseases.

This review discusses recent strategies targeting the neuroactive steroid biosynthetic pathway to enhance neurosteroidogenesis, highlighting their potential benefits for neurodegenerative and neuropsychiatric diseases, but reports no new clinical findings.

This study investigated various synthesized 5-reductase inhibitors and found that compound 6 had the highest anti-androgenic activity and receptor affinity compared to finasteride, showing potential due to its improved efficacy and bioavailability for further research in treating lower urinary tract symptoms.

This study found that gonadal steroid hormones influence alopecia areata in C3H/HeJ mice, with estradiol promoting progression and dihydrotestosterone conferring resistance to disease onset.

This article reviews anthralin's pharmacology, mode of action, and its use for psoriasis and other dermatoses, but reports no new clinical results.

In this study, analysis of FDA data revealed a substantial risk of dermatologic adverse events with aromatase inhibitors, especially anastrozole and exemestane, highlighting the importance of dermatologic monitoring during such therapies.

In this study, prolonged high-dose steroid treatment in rats caused several pathological changes, some of which regressed, particularly improvements in mammary gland tumors and pituitary-related symptoms, after stopping treatment.

This study found that using methotrexate with corticosteroids may support hair regrowth in severe alopecia areata, but adverse effects and relapses were common, suggesting more controlled trials are needed.

This review discusses female androgen insufficiency syndrome and reports no new clinical results; the authors suggest that testosterone replacement may alleviate symptoms like loss of libido and fatigue.

This study developed a validated method using UPLC-MS/MS to analyze 37 hormones in human hair, enabling broader hormonal profiling for identifying endocrine disorders.

Intramuscular triamcinolone and pulse therapy with oral predonine are effective for alopecia areata with manageable side effects, but better relapse prevention is needed.

This study found that testosterone and 5α-dihydrotestosterone affect human sebocytes differently depending on the skin region, with spironolactone inhibiting their proliferation and counteracting androgen effects in facial sebocytes.

This case report describes a 55-year-old woman with alopecia areata whose condition improved rapidly and did not recur after the surgical resection of a thymoma, suggesting a potential immunological link between alopecia areata and thymoma that warrants further investigation.

This study found that administering dutasteride did not change spermatogenesis or oxidative stress levels in rat testes, though further research is needed to confirm these findings.

In this case report, an 11-year-old girl with hypothyroidism was found to have Hashimoto thyroiditis after presenting with hair loss, short stature, and pubertal disturbances; the study emphasizes the importance of early diagnosis and personalized thyroid hormone therapy for better outcomes.

This study found that prepubertal Hispanic girls with idiopathic premature adrenarche did not show differences in 5 alpha-reductase or 11 beta-hydroxysteroid dehydrogenase activities compared to controls.