22 citations
,
September 1982 in “Journal of ultrastructure research” This study reports new cellular features and complex interaction systems in fiber differentiation, indicating more intricate cellular organization than previously recognized, including features like mast cells and primary cilia.
40 citations
,
May 2016 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that the mechanical stiffening of the human hair follicle along the first millimeter is linked to changes in the keratin network architecture and composition during keratinization.
3 citations
,
January 2018 in “Indian Dermatology Online Journal” This study found that normal physiological cutaneous changes were the most common skin changes during pregnancy in Northeast India, while specific dermatoses were rare and not significantly influenced by ethnicity or geography.
42 citations
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September 1985 in “British Journal of Dermatology” This study found that trichothiodystrophic hair shows reduced and disoriented protein deposition in follicles, with both the cuticle and cortex affected, providing localized structural insights into keratin abnormalities.
1 citations
,
January 2006 This study found that keratin fibers like human hair undergo thermal and mechanical transitions that can help assess changes from cosmetic processes such as bleaching and perm-waving.
14 citations
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December 2020 in “Journal of Investigative Dermatology” This study observed that aging leads to significant structural and biological changes in the scalp's hair follicle environment in women, which may affect hair growth.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers found that proteomic changes with age were significantly more pronounced in dermal papilla cells compared to dermal sheath and interfollicular dermal fibroblasts in the female scalp.
September 2017 in “Journal of Investigative Dermatology” In this study, the novel ASAXA-μCT imaging method identified that the shrinkage of sweat glands with aging causes dermal defects, reducing skin elasticity and contributing to wrinkling and sagging.
3 citations
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August 2017 in “Journal of evolution of medical and dental sciences” In this descriptive study, elderly patients most commonly presented with skin wrinkling, xerosis, and eczematous conditions, highlighting the difficulty in distinguishing normal age-related from pathological skin changes.
7 citations
,
August 2023 in “Skin Research and Technology” This study highlights age and sex as key factors influencing scalp parameters, thereby affecting hair health and suggesting they should be considered in developing hair care strategies.
67 citations
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December 2009 in “International Journal of Dermatology” This study suggests that hormonal receptor activity in skin regions undergoing mechanical stretching may influence extracellular matrix metabolism and the formation of SD, with variations in receptor functionality throughout lesion development stages.
21 citations
,
July 2010 in “International Journal of Cosmetic Science” This study found that hair luster decreases with age in Japanese females, primarily due to an irregular increase in fiber curvature which affects hair alignment.
1 citations
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March 2014 in “Journal of Innovative Optical Health Sciences” This study found that in mice, wool structure deteriorates as a malignant tumor develops, suggesting potential uses in cancer diagnostics.
31 citations
,
November 2016 in “Cell Reports” This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.
3 citations
,
October 2006 in “Journal of dermatology” This study reported that X-ray microscopy provides more intact images of hair's internal structure compared to transmission electron microscopy, particularly for observing fine details like cuticle coarsening and cortex cracks.
8 citations
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May 2005 in “The American journal of dermatopathology/American journal of dermatopathology” This study observed unique ultrastructural changes in a 4-year-old girl with pili trianguli et canaliculi that may affect hair shaft surface characteristics due to inner root sheath alterations.
This study found that ponytails with small fractions of gray hair have significantly lower swing height and higher damping, affecting the dynamic movement and appearance compared to those with fewer gray hairs.
May 2022 in “Experimental dermatology” In this study, hair shafts from trichothiodystrophy patients with ERCC2 mutations revealed abnormal cuticle structures and protein imbalances compared to normal hair shafts.
November 2024 in “Biophysical Chemistry” This study analyzed the swelling behavior of human hair during permanent waving treatment, finding that both the microstructure and macrostructure of intermediate filaments swell simultaneously at the initial stage, and while partially destructed by reduction, they are considerably restored through oxidation.
February 2024 in “Medicina” In this study, researchers used atomic force microscopy to capture and analyze morphological changes in the surface of healthy hair, identifying features such as pitting and rod-shaped macro-fibrillar elements, which could inform future research on hair conditions and care.
September 2024 in “Meditsinskiy sovet = Medical Council” The study observed that in women, the number of hair follicles with an internal root sheath decreases with age in the parietal region, also hinting at a reduction in hair follicle and shaft width.
January 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that ageing in women leads to significant structural and biological changes in the scalp hair follicle environment, which may affect hair growth.
This article reviews how environmental factors and aging contribute to skin and hair changes, including wrinkling, dryness, pigmentation changes, and hair thinning, but reports no new research findings.
96 citations
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January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
81 citations
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December 2007 in “Acta materialia” This study conducted in situ tensile loading experiments with atomic force microscopy to observe how conditioning treatments affect the tensile response of virgin, chemically damaged, and mechanically damaged Caucasian hair.
49 citations
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September 2004 in “Journal of the European Academy of Dermatology and Venereology” This study found that careful light microscopy using fluid-mounted hair improves detection of the pili annulati phenotype, which varies widely in expression and affects hair fragility.
3 citations
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July 2020 in “Mechanisms of Development” May 2009 in “International Journal of Cosmetic Science” In this study, permanent waving treatments, especially those using lotion B and repeated procedures, were found to significantly damage hair protein content and physical properties.
7 citations
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September 2020 in “International Journal of Cosmetic Science” This study investigated the effects of wool-derived hydrolysed keratin peptides on relaxed textured hair and found that mid- and high-molecular weight peptides improved mechanical strength and reduced breakage in different humidity conditions.
13 citations
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March 2020 in “Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy” This study used infrared spectroscopic imaging and scanning electron microscopy to reveal that alopecic hair has more irregular laminated structures and differing chemical profiles than normal hair, suggesting changes related to alopecia progression.