Pili Trianguli Et Canaliculi Is a Defect of Inner Root Sheath Keratinization

May 2005 in “ The American journal of dermatopathology/American journal of dermatopathology ”

Iftikhar Ahmed, Antonio Subtil, Douglas A Thomas

pili trianguli et canaliculi inner root sheath keratinization tonofilament desmosomal detachment cytoskeleton hair shaft

TLDR The hair defect is due to abnormal inner root sheath keratinization.

A 4-year-old Caucasian girl with pili trianguli et canaliculi exhibited unique ultrastructural changes, including tonofilament-desmosomal detachment and tonofilament clumping within inner root sheath cells. These findings suggested that the hair anomaly in this condition might be due to a compromised cytoskeleton, leading to configurational changes in the inner root sheath. Despite these changes, keratinization of the inner root sheath still occurred, which typically precedes the keratinization of the hair shaft. Therefore, the abnormally configured inner root sheath influenced the surface characteristics of the hair shaft in pili trianguli et canaliculi.

View this study on journals.lww.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Acquired Uncombable Hair Syndrome in a 39-Year-Old Woman

6 citations, August 1993 in “Archives of Dermatology”

A woman's hair changed to a dry, tangled texture that's hard to comb after treatment with spironolactone, suggesting the medication might cause such hair changes.

research Crystalline Cataract and Uncombable Hair Syndrome in a 7-Year-Old Girl

26 citations, September 1990 in “Ophthalmology”

The study found no common cause for a girl's crystalline cataract and uncombable hair, suggesting their co-occurrence might be coincidental.

research Uncombable-Hair Syndrome

12 citations, November 1987 in “Pediatric dermatology”

Four children had unmanageable pale blond hair due to uncombable-hair syndrome.

Related Community Posts Join

6 / 18 results

community Hair theory Scar tissue and Verteporfin

in Chat 26 upvotes 6 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 4 weeks ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community HRT is literal black magic. Fin 1 mg/day @ 4 years, min 2x/day @ 3 years, Estradiol 4mg/day @ 3.5 months, and Spironolactone 100mg/day @ 3.5 months (estra & spiro are medicines you should likely not take if you are a cis man)

in Progress Pictures 118 upvotes 3 months ago

User shared progress on hair regrowth using Fin 1 mg/day for 4 years, Min 2x/day for 3 years, Estradiol 4mg/day, and Spironolactone 100mg/day for 3.5 months. They noted significant hairline recovery and advised against HRT for cis men due to feminizing effects.

Related Research

2 / 2 results

research Pili Trianguli Et Canaliculi Is a Defect of Inner Root Sheath Keratinization

8 citations, May 2005 in “The American journal of dermatopathology/American journal of dermatopathology”

The hair defect is due to abnormal inner root sheath keratinization.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations, February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.