Expression of Estrogen, Androgen, and Glucocorticoid Receptors in Recent Striae Distensae
December 2009
in “
International Journal of Dermatology
”
Studysummary This study suggests that hormonal receptor activity in skin regions undergoing mechanical stretching may influence extracellular matrix metabolism and the formation of SD, with variations in receptor functionality throughout lesion development stages.
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The study suggested that increased expression of estrogen, androgen, and glucocorticoid receptors occurred in areas of the skin experiencing significant mechanical stretching, potentially influencing extracellular matrix metabolism and leading to the formation of striae distensae (SD). Hormonal receptor alterations were observed during specific time periods in SD formation, with functional differences noted at various lesion development stages. These preliminary findings were considered relevant and provided an initial step towards understanding the pathophysiology of SD.
