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This study found that testosterone enhances glucose-stimulated insulin secretion in male and female human islets, requiring conversion to DHT and E2 via SRD5A1 and aromatase.

In this study, bicalutamide at low doses was not linked to significant liver enzyme changes compared to other androgen-blocking treatments in transfeminine adolescents and young adults, suggesting its safety with careful monitoring for this population over one year.

This study reports that newly synthesized steroidal trienones exhibit higher 5α-reductase inhibitory activity than dienones in various biological models, suggesting potential use in treating androgen-dependent diseases.

This article discusses the considerations and challenges surrounding a proposed large-scale trial on testosterone-replacement therapy in older men and reports no new results.

In this study, nandrolone decanoate treatment in rats caused persistent diestrus and altered steroid receptor expression and sex hormones, especially at higher doses, with partial reversibility at lower doses over time.

This review discusses hormonal therapies for acne related to endocrine disorders and provides practical guidelines for managing hormonally influenced acne in clinical practice, but reports no new clinical results.

This study found that testosterone therapy increased bone mineral density in older men with low testosterone, and combining it with finasteride may reduce prostate enlargement associated with testosterone treatment.

This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.

This study found that testosterone therapy in trans men increased facial and body hair growth while the prevalence and severity of acne peaked at 6 months but were primarily mild after long-term treatment.

In this study, transgender adolescents treated with testosterone for a median of 12 months experienced effective virilization, including voice deepening and increased hair growth, but also showed decreased HDL cholesterol and BMD z-scores, and increased hematocrit, with no short-term safety issues reported.

This paper describes recent advancements in the synthesis of thiasteroids but reports no new experimental results, noting that introducing heteroatoms in steroidal structures has potential biological effects.

This study evaluated the stability of multiple active ingredients in TrichoSol™ for use in alopecia treatments, finding varying stability durations at room temperature—up to 180 days for some ingredients—supporting its use as a compounding vehicle in personalized therapies.

This article reviews triamcinolone acetonide as an intramuscular long-acting steroid therapy for dermatologic disorders but reports no new clinical results.

This study established a protocol using anti-steroid antibodies to differentially label epidermal cell contributors, suggesting potential applications in simplifying complex trace DNA mixtures before profiling.

This study describes a method to estimate endogenous hormone production by neutralizing an endogenous hormone with an oppositely acting hormone.

This study found that androgenic steroids, particularly androstenedione and androstanedione, significantly reduced the growth of certain dermatophytes, suggesting hormonal influence on fungal infections in hair follicles.

This study found that 3alpha-diol, an androgen metabolite, improved cognitive and affective performance in aged male rats, suggesting its role in countering age-related decline in hippocampally-influenced behaviors.

This case study highlights the complexity of managing PCOS and its symptoms in transmen, suggesting hormonal fluctuations may lead to symptomatic relief with low dose estradiol.

This source describes clascoterone, a new topical treatment for acne vulgaris that blocks androgen receptors to reduce sebaceous gland activity and inflammation, offering a lower risk of systemic side effects compared to oral treatments.

This book reviews current knowledge on testosterone, its functions, underlying mechanisms, and examines ethical and safety issues concerning its clinical and practical applications, without reporting new research findings.

This narrative review highlights the critical role of intracrine hormone production in peripheral tissues, suggesting that continuous-release subcutaneous testosterone pellet therapy may offer a more effective symptom-driven approach for aging populations, though large-scale randomized controlled trials are needed for confirmation.

This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.

In this study, finasteride treatment for male pattern baldness improved hair loss and reduced prostate size, while increasing testosterone levels and altering steroid hormone ratios without affecting gonadotropin levels.

This case report presents a 60-year-old woman with virilization and elevated adrenal androgens, where a bilateral salpingo-oophorectomy confirmed ovarian steroid cell tumor NOS, and her symptoms resolved post-operatively.

This study suggests that patients with STSD show a different pattern in androgen activation compared to healthy controls, potentially due to increased 5α-reductase activity and absent prepubertal serum DHEA surge.

This study found that a significant portion of counterfeit drugs seized among bodybuilders did not match their labels, with many containing undeclared anabolic steroids or other unexpected active ingredients.

This study reported that newly synthesized progesterone derivatives significantly reduced prostate weight in testosterone-treated hamsters, with 5alpha-reductase inhibitory activity dependent on the size of the substituent at C-17.

This study reviewed the preferences and reasons for testosterone injection therapy among 53 Canadian men with hypogonadism, finding that most opted for injections due to efficacy, ease, and cost considerations.

This review discusses androgen therapy in adolescents, detailing current practices and noting the limited use of commercially available testosterone or dihydrotestosterone formulations; no new results are reported.