The Efficacy of an Adjuvant Norethisterone (Jenapharm) Therapy in Endometrial Cancer

    January 1987 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    W Krafft, Renate Steuckardt, H Behling, Eva-Maria König, D Brückmann, J Kademann, G Schmeisser
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    TLDR Norethisterone (jenapharm) therapy is effective for endometrial cancer.
    The document from 1987 discusses the role of androgens in the development and severity of acne, noting that it can be associated with various endocrinopathies such as polycystic ovarian syndrome, ovarian tumors, or adrenal hyperplasia or tumors. These conditions may be suspected in patients with sudden onset acne, hirsutism, menstrual irregularities, cushingoid facies, acanthosis nigricans, patterned hair loss, or a deepened voice. In such cases, it is recommended to test for serum-free and total testosterone, dehydroepiandrosterone, luteinizing hormone, and follicle stimulating hormone, and to provide appropriate referral and long-term follow-up. The document also outlines hormonal therapies for acne, which include androgen receptor blockers (spironolactone, cyproterone acetate, chlormadinone, flutamide), adrenal androgen production blockers (glucocorticoids), and ovarian androgen production blockers (gonadotropin-releasing agonists and oral contraceptives), providing practical guidelines for treatment.
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