42 citations
,
February 2016 in “Science” The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.
8 citations
,
January 2000 This study found that terbinafine prevented the invasion of keratin by Trichophyton mentagrophytes in experimental models replicating human dermatomycoses.
8 citations
,
June 1995 in “Helvetica Chimica Acta” This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.
6 citations
,
August 1993 in “Archives of Dermatology” This article describes the first documented case of acquired uncombable hair syndrome in a 39-year-old woman, contributing to the understanding of this rare condition.
2 citations
,
February 2017 in “Science” The Dawn spacecraft found that Ceres has complex organic molecules and a lot of water ice, hinting it might support life.
January 2025 in “Turkish Journal of Cerebrovascular Diseases” This case report details two consanguineous patients with cerebral autosomal recessive arteriopathy, both having the same HTRA1 gene mutation, but exhibiting different clinical presentations, including one with epileptic seizures and lobar hemorrhages—previously undocumented in this condition.
This chapter reviews the epidemiology, clinical manifestations, diagnosis, treatment, and outcomes of severe acute respiratory syndrome (SARS) in children, but presents no new clinical results.
82 citations
,
January 2002 in “Journal of drug targeting” This study found that drug delivery through human scalp skin may be more effective for lipophilic and hydrophilic drugs compared to abdominal skin, highlighting the potential of intrafollicular delivery methods.
66 citations
,
February 2010 in “CrystEngComm” Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
66 citations
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April 1995 in “The journal of cell biology/The Journal of cell biology” In this study, researchers reported that a keratinocyte growth factor-Ig fusion protein could specifically detect and localize KGFRs in epithelial tissues, suggesting a method for histochemical detection of growth factor receptors.
59 citations
,
June 2023 in “Nature Aging” This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.
57 citations
,
July 2005 in “Genetics” In this study on Drosophila wings, researchers identified 435 genes with significant expression changes during wing hair morphogenesis, and found new phenotypes for 9 genes through functional validation.
55 citations
,
September 2014 in “Development” In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.
47 citations
,
May 1995 in “Journal of Investigative Dermatology” Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.
34 citations
,
October 2021 in “Scientific Reports” This study found that nobiletin-loaded vesicles effectively restored skin condition in a mouse model of skin cancer, suggesting they are a promising treatment delivery system.
27 citations
,
July 2017 in “Scientific Reports” This study found that conditional knockout of N-WASP in keratinocytes of mice led to skin barrier defects, increased immune cell infiltration, and hyperproliferation of keratinocytes, indicating its crucial role in skin homeostasis.
22 citations
,
February 2008 in “Journal of Neurochemistry” This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.
17 citations
,
June 2014 in “Journal of Ultrasound in Medicine” This study found that sonography and electron microscopy revealed distinct abnormalities in hair follicle morphology in patients with androgenetic alopecia, which may aid in diagnosing and managing the condition.
14 citations
,
July 2016 in “Anatomical Science International” This study revealed that in androgenic alopecia, the proximal attachment of the arrector pili muscle to the hair follicle is often lost or significantly reduced.
8 citations
,
June 2019 in “Pharmaceutical research” This study found that using short durations of heat with chemical penetration enhancers improved isotretinoin delivery to human skin, especially via the hair follicles.
5 citations
,
May 1999 in “Dermatologic Surgery” Lasers can effectively treat pseudofolliculitis barbae, but insurance often doesn't cover it, possibly due to racial bias.
3 citations
,
May 1999 in “Dermatologic Surgery” Dr. Connelly agrees that linear basal cell carcinomas might be more aggressive but highlights the study's lack of clear criteria to identify them.
2 citations
,
March 2022 in “Research Square (Research Square)” In this study, the expression of certain hair follicle-related genes differed between growth phases in Angora goats, with HOXC13 showing overexpression during the anagen phase, potentially influencing the mohair's shine and texture.
2 citations
,
November 2014 This chapter reviews common cosmetic dermatology techniques but presents no new findings; it discusses treatments like emollients and laser therapy for conditions like photoaged skin and acne scarring.
2 citations
,
June 2022 in “Scientific reports” In this study, one type of commercial culture medium supported expression of stem cell markers in hair follicle epithelial stem cells, but their differentiation potential and hair follicle-inducing ability declined over time.
November 2022 in “Research Square (Research Square)” This study found that HOXC13 gene expression was significantly higher during the anagen phase in Angora goats, potentially contributing to the mohair's shiny and silky nature.
This study found that Nubian ibex have developed genetic adaptations in response to their desert environment, including enhanced skin barrier, DNA repair, viral response, and metabolism of toxic compounds.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study suggests that the adrenal gland may contribute to prostate cancer treatment resistance and indicates potential steroid production or dependency in ovarian cancer.
January 2012 in “Methods in pharmacology and toxicology” This review discusses the expanding understanding of TRPV3's role in pain and skin pathology, while highlighting the need for further pharmacological research to fully resolve its functions.
May 1999 in “Dermatologic Surgery” The cell culture medium "RPMI" might slightly improve hair graft survival, but not by a significant amount.