18 citations
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October 2005 in “International Journal of Pharmaceutics” This study found that incorporating 0.5% TPGS into topical minoxidil solutions enhanced hair growth in mice, although increasing TPGS to 2% decreased effectiveness.
10 citations
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March 2015 in “American journal of primatology” This study found that ringtailed lemurs consuming leucaena in Berenty absorb mimosine, which causes alopecia without affecting body condition or organ toxicity; this may increase infant mortality due to alopecic mothers.
April 2026 in “Mendeley Data” Topical hair loss treatments have a stronger placebo effect than systemic ones.
April 2026 in “Mendeley Data” Topical treatments for hair loss have a stronger placebo effect than systemic ones.
July 2025 in “Journal of Investigative Dermatology” Leflunomide may reduce the risk of alopecia areata, while methotrexate, cyclosporine, and rituximab may increase it.
12 citations
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June 2020 in “Lupus” This study found that treating a murine model of systemic lupus erythematosus with early and optimally dosed mesenchymal stem cells effectively suppressed disease severity.
May 2026 in “Skin Appendage Disorders” This study found that combining platelet-rich plasma with systemic therapies for androgenetic alopecia may result in greater improvements in hair density and width than using PRP alone, though the differences were not statistically significant.
8 citations
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April 1988 in “Journal of endocrinological investigation” This study found that topically administered spironolactone in healthy volunteers resulted in no detectable systemic absorption or changes in related hormone levels over 72 hours, indicating local effect only.
In this case study, a 12-year-old boy with alopecia totalis experienced hair regrowth on the side of his scalp treated with a combination of systemic steroids and dithranol, suggesting a potential synergistic effect that may help manage severe alopecia areata with minimal side effects.
November 2025 in “JEADV Clinical Practice” In this retrospective cohort study, patients using leflunomide for primary autoimmune conditions showed a decreased risk of developing alopecia areata, while those using methotrexate, cyclosporine, and rituximab had an increased risk.
March 2025 in “Mediterranean Journal of Rheumatology” This study concluded that laser hair removal using Alexandrite laser emitting red and infrared light appears safe and does not significantly affect the disease activity of Systemic lupus erythematosus.
15 citations
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September 2021 in “Journal of Clinical Medicine” This study observed that in children who unintentionally consumed high-dose oral minoxidil, 65% developed hypertrichosis, predominantly on the face, and 15% experienced mild systemic side effects.
November 2024 in “International Medical Case Reports Journal” Glucocorticoid treatment in lupus can cause oral lesions, which need early diagnosis and comprehensive care.
In this study, PRP combined with systemic therapy for androgenetic alopecia showed higher, but not statistically significant, improvements in hair density and width compared to PRP alone, with no increase in side effects; further prospective studies are recommended.
This study found that androgenetic alopecia patients treated with a combination of PRP and systemic therapy experienced greater but non-significant improvements in hair density and width compared to PRP monotherapy, without additional adverse effects, suggesting potential benefits for further exploration of combination regimens.
January 2025 in “Hospital Pharmacology - International Multidisciplinary Journal” In this study, researchers explored the effects of various medications on eye health, noting that systemic and local ophthalmic drugs can lead to both widespread and specific ocular side effects, with serious adverse events most associated with neurotropic, immunotropic, and antitumor medications.
January 2018 in “Springer eBooks” This chapter reviews the skin side effects associated with targeted cancer therapies and emphasizes the importance of collaboration between oncologists and dermatologists without reporting new results.
20 citations
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February 1977 in “Circulation” Minoxidil lowers blood pressure and increases heart efficiency, but may raise lung artery pressure in some people.
November 2025 in “Frontiers in Nutrition” Olive leaf extract may help reduce aging signs in postmenopausal women.
July 2026 in “Annals of Medicine and Surgery” This study found that arthritis and mucocutaneous features are common at early stages of SLE, while sicca, vasculitis, and hematologic manifestations tend to increase as the disease progresses.
97 citations
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January 2006 in “Dermatology” This study found that intramuscular triamcinolone acetonide or pulse therapy effectively treats alopecia areata with manageable side effects, but further strategies are needed to reduce relapse rates.
6 citations
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November 2008 in “Journal of Dermatological Science” Certain proteins involved in DNA modification may affect the genetic changes in systemic lupus erythematosus and could indicate the disease's activity.
2 citations
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June 1987 in “British Journal of Dermatology” This study demonstrates that warming hands can restore normal blood flow in patients with systemic sclerosis, making their response to cooling similar to that of healthy controls.
1 citations
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January 2018 in “Indian Journal of Dermatology/Indian journal of dermatology” This report describes cases of transient thyrotoxicosis potentially linked to oral retinoid treatment, suggesting a possible mechanism involving increased iodine uptake by thyroid cells.
January 2007 in “Yearbook of Dermatology and Dermatologic Surgery” Intramuscular triamcinolone and pulse therapy with oral predonine are effective for alopecia areata with manageable side effects, but better relapse prevention is needed.
July 1996 in “Clinical and Experimental Dermatology” This study found that a single topical application of calcipotriol ointment did not affect systemic calcium levels in patients with chronic plaque psoriasis.
78 citations
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May 1989 in “The Journal of Clinical Endocrinology & Metabolism” This study found that in hirsute women, daily treatment with 200 mg spironolactone significantly reduced hair growth rates and hair shaft diameters on various body areas over 12 months.
January 2005 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” In this study, a 0.5% addition of TPGS to topical minoxidil solutions increased hair growth in mice, but higher concentrations reduced this benefit.
November 2023 in “Journal of Investigative Dermatology” JAK inhibitors are effective and generally safe for treating alopecia areata, but monitoring for side effects is important.
January 1989 in “Oxford University Research Archive (ORA) (University of Oxford)” This study found that spironolactone effectively reduced hair growth in hirsute women over 12 months and was generally well tolerated.