5 citations
,
January 2020 in “Skin appendage disorders” This study found that oral dutasteride increased hair count more than intralesional administration in androgenetic alopecia, but more research is needed for a reliable comparison.
5 citations
,
December 1979 in “Clinical and Experimental Dermatology” Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.
March 2026 in “Editora Pasteur eBooks” This chapter provides a comprehensive review of androgenetic alopecia, covering its key physiological mechanisms, diagnostic methods, and a variety of treatment options ranging from topical therapies to aesthetic and regenerative procedures, emphasizing recent advances observed in dermatological practice.
December 2022 in “International Journal of Biomedicine” This review discusses the potential role of androgens in COVID-19's pathophysiology and their possible link to hair disorders, but reports no new clinical results.
This chapter reviews the causes, prevalence, and prognosis of androgenetic alopecia and discusses treatments like topical minoxidil and systemic finasteride to stop hair loss and potentially increase hair density.
4 citations
,
April 1999 in “Dermatologic Clinics” Androgens, like DHT, affect hair growth and treatments like finasteride may help.
5 citations
,
May 2020 in “Clinical and Experimental Dermatology” This correspondence discusses clascoterone as a potential new treatment for androgenetic alopecia but reports no clinical results.
2 citations
,
August 2016 in “Experimental Dermatology” This review discusses the efficacy and safety of oral finasteride for treating male pattern baldness and the potential persistent side effects, but no new results are reported.
370 citations
,
September 1999 in “The New England Journal of Medicine” This article discusses the treatment of androgenetic alopecia and alopecia areata with finasteride and minoxidil but reports no new clinical results.
131 citations
,
August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
118 citations
,
April 1998 in “Dermatologic Clinics” This review discusses the advancements in understanding and treating androgenetic alopecia and alopecia areata but reports no clinical findings; the authors emphasize the need for further research on molecular control mechanisms.
87 citations
,
May 2018 in “Scientific Reports” This study found that in healthy men, higher levels of free testosterone were associated with a stronger immune response to the influenza vaccine, suggesting androgens may function as immunomodulators rather than strict immunosuppressants.
81 citations
,
March 2009 in “Seminars in Cutaneous Medicine and Surgery” This review discusses the classifications, diagnostic methods, and treatment strategies for female pattern hair loss, but reports no clinical results.
62 citations
,
July 1993 in “Journal of Investigative Dermatology” Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
59 citations
,
May 2014 in “Expert Opinion on Therapeutic Targets” This review discusses current therapeutic targets and treatments for androgenic alopecia but reports no clinical results; the authors highlight the challenge of developing multi-target drugs for effective treatment.
51 citations
,
January 2003 in “Hormone Research in Paediatrics” This review discusses hormonal influences on hair growth and suggests that understanding hormone-gene interactions may improve treatment of hirsutism and alopecia, but reports no new clinical findings.
47 citations
,
April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.
37 citations
,
May 1999 in “Australasian Journal of Dermatology” This review discusses neutrophil-associated and infiltrative scarring alopecias, as well as promising new treatments, but reports no new clinical results.
36 citations
,
September 2018 in “American Journal of Clinical Dermatology” This study found that a topical combination of 0.25% finasteride and 3% minoxidil may increase hair diameter more effectively than 3% minoxidil alone in postmenopausal women with female pattern hair loss.
35 citations
,
January 2014 in “Postepy Dermatologii I Alergologii” This study found that increased dihydrotestosterone levels were observed in both androgenetic alopecia patients and controls, suggesting that follicle sensitivity to DHT may be more critical than DHT levels for alopecia development.
34 citations
,
July 2020 in “Frontiers in immunology” This mini-review discusses the role of androgens, specifically testosterone and dihydrotestosterone, in the pathogenesis of autoimmune liver diseases and reports no new results.
32 citations
,
December 2017 in “Journal of Drug Delivery Science and Technology” This study found that co-delivery of minoxidil and caffeine in transfersomes with an optimized polysorbate formulation enhanced hair length and weight in vivo.
29 citations
,
September 2012 in “Dermatologic Clinics” This article reviews the causal mechanisms of hair follicle disorders, focusing on inflammation, genetics, environment, and hormones, but it reports no new clinical results.
29 citations
,
February 2007 in “Hormone and metabolic research” This study found that antisense oligonucleotides can significantly reduce androgen receptor expression in cultured human sebocytes and may offer new therapeutic possibilities for androgen-associated skin diseases.
29 citations
,
December 1998 in “Seminars in Cutaneous Medicine and Surgery” This review examines recent approvals and emerging treatments for androgenetic alopecia, discussing newly approved drugs like Propecia and Rogaine Extra Strength 5%, but without presenting new clinical results.
28 citations
,
May 2015 in “Addiction Biology” This study found that early life stress significantly affects hedonic sensitivity to high-palatable food by altering gonadal hormones in prenatally-stressed male and female rats, with sex-dependent changes in reward-related behaviors and neurochemistry.
26 citations
,
January 2019 in “Expert Opinion on Investigational Drugs” This review explored the new and emerging treatments for androgenetic alopecia and alopecia areata, finding that JAK inhibitors show promise for alopecia areata, while advancements in stem-cell research may eventually lead to new and improved treatments for androgenetic alopecia.
26 citations
,
January 2013 in “BMJ Open” This meta-analysis reports that vertex baldness is associated with an increased risk of coronary heart disease, particularly in younger men, while no significant link was found for frontal baldness.
21 citations
,
January 2003 in “Skin pharmacology and physiology” This study found that dutasteride completely suppressed the formation of 5alpha-dihydro metabolites in cultured human skin cells, suggesting its potential use in acne and androgenetic alopecia.
20 citations
,
April 2021 in “Journal of Womens Health” This guideline provides evidence-based recommendations for prescribing testosterone therapy to women with hypoactive sexual desire disorder, noting a moderate therapeutic benefit but highlighting limited data and regulatory challenges.