January 2015 in “Springer eBooks” This chapter reviews the potential of adipose-derived stem cells for skin aging and hair loss treatments but reports no new experimental results; the authors highlight these stem cells as a promising regenerative resource.
March 2026 in “JPRAS Open” This source reviews the potential of exosome-based therapies for various types of hair loss, highlighting promising preclinical mechanisms and signaling pathways such as Wnt/β-catenin, PI3K/AKT, VEGF, and TGF-β involved in the regenerative properties of extracellular vesicles.
This study suggests that incorporating exogenous melatonin in the treatment of certain skin disorders, like psoriasis and eczema, can improve treatment efficiency, normalize immune parameters, and reduce disease relapses.
April 1992 in “Current opinion in therapeutic patents” This study reports the development of novel 4-amido-Δ4,6-steroids as potential inhibitors of 5α-reductase, showing promising in vitro results for conditions like acne and benign prostatic cancer.
December 2020 in “International journal of research in ayurveda and pharmacy” This review covers hair anatomy, common hair diseases, diagnostic approaches, management, and hair care, but reports no new clinical findings; the authors highlight the importance of proper hair care knowledge.
1 citations
,
January 2001 in “Endocrine Practice” This study suggests that topical finasteride may benefit women with facial hirsutism, based on observations from a small sample.
198 citations
,
January 1998 in “Dermatology” This review discusses human sebocyte in vitro models for studying sebaceous gland function and control but reports no new clinical results, highlighting hormonal effects and the impact of retinoids on sebocyte activity.
6 citations
,
November 2024 in “Molecular Medicine” This review highlights that hormones significantly influence the wound healing process by coordinating cellular and molecular activities, and hormonal therapy is emerging as a promising treatment, with current research focusing on optimizing dosages and minimizing side effects.
111 citations
,
August 2002 in “Journal of Medicinal Chemistry” This study reports that 2-(1-Adamantyl)-4H-thiochromen-4-on-6-O-sulfamate is the most potent steroid sulfatase inhibitor identified so far, exhibiting 170-fold higher activity than the lead compound estrone sulfamate.
9 citations
,
April 2011 in “PubMed” This review discusses spironolactone's dermatologic applications, particularly for conditions like hirsutism and female pattern hair loss, but reports no new results; it also highlights safety concerns in pregnancy and men.
24 citations
,
October 2012 in “The International Journal of Biochemistry & Cell Biology” In this study, testosterone protected female embryonic heart cells from metabolic stress by being converted into metabolites that activate estrogen receptors and up-regulate certain mitochondrial channel proteins.
1 citations
,
April 2025 in “Phycology” In this review, researchers highlight recent findings on the cosmeceutical applications of phlorotannins from brown seaweeds, emphasizing their promising bioactive properties since 2020.
January 2026 in “International Journal of Molecular Sciences” This review discusses the diverse industrial applications of hemp beyond traditional fiber uses, highlighting its phytochemical components with antioxidant and antimicrobial properties that are explored in agrochemicals, cosmetics, and food sectors.
7 citations
,
October 2024 in “Cells” This review discusses the potential of platelet-rich plasma in regenerative medicine and aging-related diseases but notes that clinical efficacy remains unclear due to varying study results and preparation inconsistencies.
38 citations
,
September 2019 in “Chinese Medical Journal” This review discusses the cardiovascular risks associated with anabolic-androgenic steroid use and reports that, despite known toxic effects, further research is needed to clarify the causality of these risks.
59 citations
,
May 2014 in “Expert Opinion on Therapeutic Targets” This review discusses current therapeutic targets and treatments for androgenic alopecia but reports no clinical results; the authors highlight the challenge of developing multi-target drugs for effective treatment.
20 citations
,
September 2005 in “Endocrinology” This study identified novel selective androgen receptor modulators with enhanced in vivo pharmacological activity through structure-activity relationship analysis in castrated rats.
15 citations
,
August 2016 in “Current Urology Reports” Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.
253 citations
,
March 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses the hypothesis that polycystic ovary syndrome may originate in fetal life due to prenatal androgen exposure, but reports no new clinical results.
38 citations
,
September 2006 in “Journal of Dermatological Science” This study evaluated the effect of 2% ketoconazole lotion for androgenetic alopecia, but the results regarding its effectiveness on clinical appearance remained unclear.
25 citations
,
June 2017 in “Molecular and Cellular Endocrinology” This review discusses the negative effects of anabolic androgenic steroids on various organ systems in men and reports no new results, highlighting the need for physician awareness.
233 citations
,
November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.
124 citations
,
July 2012 in “Archives of Dermatological Research” This review discusses the roles of androgens and androgen receptors in skin-related disorders and suggests that targeting androgen receptors may be a more effective treatment strategy.
17 citations
,
January 2015 in “MedChemComm” New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.
15 citations
,
January 1998 in “Journal of Clinical Periodontology” Finasteride helps treat hair loss by blocking enzyme activity.
12 citations
,
February 2010 in “Tetrahedron Letters” This article describes the synthesis of novel polyamine-modified minoxidil analogs and conjugates to potentially enhance minoxidil's biological activity, selectivity, and water solubility, but reports no new biological results.
11 citations
,
October 2015 in “Clinical and Experimental Dermatology” This study found that an extract from the root of Sophora flavescens Aiton significantly improved hair growth in patients with androgenetic alopecia over 6 months.
9 citations
,
August 2000 in “Journal of Periodontal Research” Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
7 citations
,
January 1994 in “Annual Reports in Medicinal Chemistry” This review discusses hormonal manipulation for conditions like prostatic disorders and skin issues and highlights promising treatments like casodex and finasteride, but it reports no new clinical results.
5 citations
,
January 2017 in “Biomedical Research-tokyo” This review examines the long-term health risks of anabolic-androgenic steroid abuse in athletes, reporting various physical and psychological side effects without sufficient benefits.