Traditional and Alternative Methods of Acne Treatment

The document reviews traditional and alternative acne treatments, focusing on reducing side effects and improving efficacy. Traditional treatments like isotretinoin and spironolactone are effective but have side effects such as skin irritation and dryness. Spironolactone shows promise, particularly in women, with a 75% reduction in inflammatory lesions in clinical trials. Clascoterone, a new topical anti-androgen, has shown significant efficacy and a favorable safety profile. Benzoyl peroxide remains effective against Cutibacterium acnes. The document emphasizes the need to limit oral antibiotic use due to rising antibiotic resistance and suggests more evidence is needed to fully endorse spironolactone for acne treatment.