Traditional and Alternative Methods of Acne Treatment

    May 2024 in “ Aktualʹnì problemi sučasnoï medicini: Vìsnik Ukraïnsʹkoï medičnoï stomatologìčnoï akademì ”
    O. Bezeha, Ya.О. Yemchenko, K.V. Vasylyeva, I.B. Popova, V.I. Kameniev
    From the encyclopedia
    Spironolactone →

    powerful topical and oral anti-androgen used mostly by women

    Clascoterone →

    a novel topical treatment that inhibits DHT on androgen receptors

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    Studysummary This review discusses the multifactorial pathogenesis of acne and current treatment strategies including the use of isotretinoin and spironolactone, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviews traditional and alternative acne treatments, focusing on reducing side effects and improving efficacy. Traditional treatments like isotretinoin and spironolactone are effective but have side effects such as skin irritation and dryness. Spironolactone shows promise, particularly in women, with a 75% reduction in inflammatory lesions in clinical trials. Clascoterone, a new topical anti-androgen, has shown significant efficacy and a favorable safety profile. Benzoyl peroxide remains effective against Cutibacterium acnes. The document emphasizes the need to limit oral antibiotic use due to rising antibiotic resistance and suggests more evidence is needed to fully endorse spironolactone for acne treatment.
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