27 citations
,
January 1984 in “Pharmacology & Therapeutics” This review discusses androgen manipulation strategies for conditions like benign prostatic hyperplasia and prostatic carcinoma but reports no new clinical results.
23 citations
,
December 2004 in “Differentiation” This article reviews the interaction between sex hormone pathways and morphogenesis-related signaling in epithelial organ development, using a chicken model to propose testable hypotheses, but reports no new clinical results.
23 citations
,
January 2003 in “Journal of Pediatric Endocrinology and Metabolism” This study observed that the use of hormonal hair products remains common among US Army School personnel, with higher use rates among non-white, female, and enlisted individuals.
11 citations
,
January 1991 in “Urology” This article reviews the potential of combining antiandrogenic and antiestrogenic treatments for BPH, highlighting aromatase inhibitors, but presents no new clinical results; further research is needed.
8 citations
,
January 1996 in “Gynecological Endocrinology” This review evaluates therapies for hyperandrogenism, highlighting cyproterone acetate as the preferred treatment due to its potency and tolerability in managing symptoms in women.
3 citations
,
December 2016 in “Sexual medicine reviews” This review discusses methods for improving study design and evaluation in sexual health literature and reports no new clinical results; it highlights current methodological issues and the benefits of validated questionnaires.
3 citations
,
January 2010 in “Elsevier eBooks” The document describes various skin conditions, their features, and treatments but lacks detailed study size information.
December 2011 in “Drug Research” The document shows the state of pharmaceutical patents as of 1999, focusing on treatments for various diseases.
May 1993 in “Drugs & Therapy Perspectives” Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.
2 citations
,
October 1988 in “Steroids” This study found that in non-obese women with moderate body hair growth, DHEA-S and prolactin levels were higher, and SBP was lower compared to controls, which may inform treatment decisions.
1 citations
,
November 2019 in “Archives of breast cancer” This review discusses non-oral hormonal contraceptives and other exogenous steroid hormones, reporting they are generally safe for temporary use in women without breast cancer, but data are limited.
64 citations
,
January 1985 in “Clinical endocrinology” In this study, treatment with the oral contraceptive containing 30 μg ethinyl oestradiol and 150 μg desogestrel significantly reduced androgen-dependent hair growth in hirsute women over one year.
3 citations
,
April 1977 in “PubMed” In this study, patients with varying severities of acne, seborrhoea, and hirsutism responded differently to Cyproteronacetate and Ethinyloestradiol treatment, with improvement rates dependent on symptom severity and treatment duration.
3 citations
,
October 1993 in “Endocrinology” In this study, finasteride inhibited progesterone synthesis in mouse-derived MA-10 Leydig tumor cells by blocking cholesterol side-chain cleavage, but human and rat cells showed minimal sensitivity.
116 citations
,
May 1992 in “The American Journal of Medicine” This study found that flutamide-induced liver toxicity in prostate cancer patients was very rare, occurring in only 0.18% of cases with clinical manifestations, and symptoms resolved after discontinuing the drug.
93 citations
,
February 2009 in “Annals of the New York Academy of Sciences” This review describes the roles of 5α-reductase isozymes in prostate development and pathology and reports no new clinical results.
14 citations
,
October 1977 in “The Lancet”
10 citations
,
November 2014 in “Sexual medicine reviews” This review discusses the management options for recurrent ischemic priapism, noting that ketoconazole, finasteride, and other hormonal therapies may be effective but can have significant side effects; it reports no new clinical findings.
9 citations
,
April 2015 in “Dermatologic Therapy” This review discusses the use of hormonal therapies for managing acne vulgaris in adult women and reports no new clinical results, emphasizing the chronic and severe nature of acne in this population.
1 citations
,
May 2002 in “British Journal of Dermatology” This article provides an overview of hair density, hair diameter, and the prevalence of female pattern hair loss but reports no new clinical findings.
May 2002 in “British Journal of Dermatology” A pregnant woman's skin condition improved after giving birth, possibly due to high estrogen levels during pregnancy.
May 2002 in “British Journal of Dermatology” This brief article is a response from the authors about hair density, hair diameter, and female pattern hair loss, and it reports no new clinical findings.
2 citations
,
December 1994 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study concluded that a regimen of transdermal estradiol and oral medroxyprogesterone acetate effectively reduces hirsutism while minimizing side effects in women with polycystic ovary syndrome.
9 citations
,
April 2018 in “Biology of reproduction” This study concluded that dietary changes alter serum progesterone and estradiol levels in late gestation ewes, likely due to metabolism rather than changes in placental steroid synthesis.
1 citations
,
January 2003 in “Expert Opinion on Therapeutic Patents” This review discusses the development and potential therapeutic applications of steroid sulfatase inhibitors for hormone-dependent disorders and cognitive dysfunction, reporting no new clinical results.
6 citations
,
April 2004 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that four new progesterone derivatives reduced prostate weight in gonadectomized hamsters, suggesting potent in vivo antiandrogenic effects similar to finasteride.
60 citations
,
June 2007 in “Pharmacology Biochemistry and Behavior” In this study, withdrawal from progesterone and treatment with finasteride were associated with increased signs of depression-like behavior in female mice, suggesting decreased allopregnanolone levels may play a role.
April 1992 in “Current opinion in therapeutic patents” This study reports the development of novel 4-amido-Δ4,6-steroids as potential inhibitors of 5α-reductase, showing promising in vitro results for conditions like acne and benign prostatic cancer.
78 citations
,
January 2000 in “Gynecological Endocrinology” This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.
5 citations
,
September 2024 in “Maturitas” In this study, an ultra-low dose combination of estradiol and dydrogesterone significantly reduced hot flushes and improved health-related quality of life among a multi-ethnic population of postmenopausal women, with no notable difference in serious adverse events compared to placebo.