research Androgen Excess Is the Key Element in Polycystic Ovary Syndrome
Too much male hormone is the main cause of Polycystic Ovary Syndrome.
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research Inhibitory Influence of Agmatine on Catamenial-Like Seizure Susceptibility in Progesterone Withdrawn Female Rats
Agmatine may help reduce seizures linked to hormone changes in female rats.
research Stromal Cells of the Human Postmenopausal Ovary Display a Distinctive Biochemical and Molecular Phenotype
Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.
research Ton1 Recruiting Motif 21 Positively Regulates the Flavonoid Metabolic Pathway at the Translational Level in Arabidopsis Thaliana
TRM21 helps control flavonoid production and root hair growth in Arabidopsis thaliana.
research Insights Learned from L457(3.43)R, an Activating Mutant of the Human Lutropin Receptor
The L457(3.43)R mutation in the human lutropin receptor causes increased activity and hormone insensitivity, leading to precocious puberty.
research Polycystic Ovary Syndrome: Detailed Examination and Management Strategies
PCOS is a genetic disorder affecting women's reproductive health, with treatments focused on symptoms like insulin resistance and fertility.
research Estrogen-Dependent Development of Sex Differences in Somatostatin Neurons of the Hypothalamic Periventricular Nucleus
Male rats have more somatostatin neurons than females due to testosterone converting to estrogen during early development.
research A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs
About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.
research Therapeutic Control of Androgen Action
Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.
research The Evaluation and Treatment of Hirsute Women
Excessive body hair in women can be caused by various conditions and treated with medication like Diane® 35 or androgen blockers.
research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy
Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.
research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
research Dermatological Problems of Puberty
Puberty often causes skin issues like acne and excessive sweating, and treatments require patience as results may vary.
research Elevated Fasting Insulin Is Associated With Cardiovascular and Metabolic Risk in Women With Polycystic Ovary Syndrome
High fasting insulin levels in women with PCOS are linked to a higher risk of heart and metabolic problems.
research Nutritional Management of Menopausal Women
Eating a balanced diet with specific nutrients can help manage menopause symptoms and prevent related health issues.
research Effects of Finasteride on Chronic and Acute Ethanol Withdrawal Severity in the WSP and WSR Selected Lines
Finasteride reduces alcohol withdrawal severity and anxiety in mice, but may increase withdrawal severity in some cases.
research Vitamin D Receptor Polymorphisms and Polycystic Ovary Syndrome: A Systematic Review
The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.
research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.
research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry
Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.
research Genetic Screening of Non-Classic CAH Females with Hyperandrogenemia Identifies a Novel CYP11B1 Gene Mutation
A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.
research PCOS: Perspectives from a Pediatric Endocrinologist and a Pediatric Gynecologist
The document concludes that early and personalized treatment for PCOS in adolescents is crucial to manage symptoms and prevent long-term health issues.
research The 5α-Reductase Inhibitor Dutasteride but Not Finasteride Protects Dopamine Neurons in the MPTP Mouse Model of Parkinson’s Disease
Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.
research Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review
Some plants with flavonoids may help treat hair loss and promote hair growth.
research Dihydrotestosterone Induces p27 Degradation via Direct Binding with SKP2 in Ovarian and Breast Cancer
Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.
research Nonclassic Congenital Adrenal Hyperplasia: An Overview
Nonclassic congenital adrenal hyperplasia is a common genetic disorder that can cause a range of symptoms and requires personalized treatment.
research Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata
Regenerative therapies show promise for treating vitiligo and alopecia areata.
research Adrenal Disorders and the Pediatric Brain: Pathophysiological Considerations and Clinical Implications
Adrenal disorders can cause lasting brain and behavior issues in children.
research Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling
Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.
research Treatment of Hyperandrogenism in Women
Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
research Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells
Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.