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Tofacitinib and ruxolitinib are effective and safe for treating various autoimmune skin and joint disorders.

JAK inhibitors for alopecia areata are linked to minor side effects like headache and acne, but not to an increased risk of serious adverse events.

Tofacitinib treatment significantly improved a patient's psoriasis, psoriatic arthritis, and alopecia universalis.

Ruxolitinib significantly improves multiple autoimmune conditions in APS-1 patients.

The health of the gut may be important in developing new ways to prevent, diagnose, and treat alopecia areata.

A patient with alopecia had hair regrowth with tofacitinib but developed a skin reaction, choosing to continue the treatment despite the side effect.

Tyrosine kinase inhibitors show promise in treating some skin diseases but their definitive role in dermatology is still unclear.

FLCN helps control iron levels in cells.

Abrocitinib effectively treated severe atopic dermatitis and mild alopecia areata in a 12-year-old boy after dupilumab failed.

Tofacitinib successfully treated vitiligo in a patient with lupus without side effects.

Upadacitinib effectively treated a patient with multiple inflammatory conditions.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Lactate production is important for activating hair growth stem cells.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Both ruxolitinib and tofacitinib are effective and safe for treating severe alopecia areata, but relapses are common.

Topical JAK inhibitors may help treat some skin conditions but need more research.

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

JAK inhibitors help hair regrowth in alopecia areata but have a high risk of side effects.

Baricitinib may effectively treat oral lichen planus.

Janus kinase inhibitors are effective and generally safe for treating hair loss in adults with alopecia areata.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Stem cell niches support, regulate, and coordinate stem cell functions.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.