21 citations
,
February 2015 in “Journal of Feline Medicine and Surgery” This study found that negative pressure wound therapy combined with skin grafting is a feasible method for treating soft tissue and skin defects in cats, achieving a high graft take rate and satisfactory outcomes.
5 citations
,
July 2022 in “Journal of Clinical Medicine” This study found histopathological evidence of hypertrophy in nerve endings that may explain the cutaneous neurosensory symptoms in some long COVID-19 patients.
April 2022 in “Journal of The American Academy of Dermatology” This article discusses scalp neuropathy in androgenetic alopecia and suggests that changes in tactile sensation due to Aβ fibers and increased nociception from circ-HTMR may be involved.
5 citations
,
August 2023 in “Skin Research and Technology” In this study, fMRI results suggested that mechanical stimulation evoked a stronger prickle sensation comprising both pain and itch on hairy skin compared to glabrous skin.
94 citations
,
January 2007 in “Cutaneous and Ocular Toxicology” This review discusses the long-term cutaneous and ocular complications from sulfur mustard exposure in the Iranian population, identifying pruritus and malignant changes as significant issues and highlighting eye surface damage leading to visual decline.
28 citations
,
April 1936 in “Journal of the American Medical Association” This report describes a case where applying fresh aloe vera leaf to roentgen dermatitis resulted in significant skin healing and reduced itching within five weeks.
15 citations
,
October 2006 in “Journal of the American Academy of Dermatology” This case report describes subcutaneous emphysema in a patient's forearm as a rare complication of liquid nitrogen spray used on hypertrophic actinic keratosis, resolving spontaneously within a day.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that structural changes in the TRPV3 channel are linked to severe skin conditions like Olmsted syndrome, with differences observed between heat-activated and resting states.
March 2005 in “Journal of The American Academy of Dermatology” Itch is a common symptom in patients with chronic venous insufficiency, often accompanied by burning and pain.
March 2005 in “Journal of The American Academy of Dermatology” This article highlights the lack of research on the prevalence and characteristics of pain and itch in early stages of mild to moderate varicose vein disease, without reporting new findings.
5 citations
,
July 1988 in “Facial Plastic Surgery” Tissue expansion is a useful method for reconstructive surgery with good results and room for further enhancement.
April 2019 in “Journal of Investigative Dermatology” This study found that post-hematopoietic cell transplantation epidermal grafting significantly reduced chronic wound size in patients with recessive dystrophic epidermolysis bullosa.
10 citations
,
May 2024 in “BioEssays” This review examined the role of the ion channel TRPV3 in warmth sensation and skin physiology, discussing controversies around its direct contribution to temperature perception, its involvement in skin health, and its potential as a therapeutic target for skin diseases.
1 citations
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January 2012 in “Elsevier eBooks” The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.
6 citations
,
June 2016 in “The anatomical record” This study found that Merkel cells in dogs are most numerous in sensory receptive areas like oral mucosa and facial skin, indicating a potential role in tactile sensation.
71 citations
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February 2020 in “Journal of Translational Medicine” This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.
123 citations
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November 2003 in “Neuroscience Letters” In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.
December 2024 in “African Journal of Biomedical Research” This study reported that the combined use of dexmedetomidine and ketamine, along with peripheral nerve blocks, provided adequate sedation and analgesia with maintained hemodynamic stability in patients undergoing minor surgical procedures like split skin grafting.
29 citations
,
November 2013 in “Expert Review of Dermatology” This article reviews potential causes and treatments for sensitive skin and reports no new clinical results; the authors emphasize neurogenic inflammation and cosmetic choices as key factors in managing the condition.
94 citations
,
January 2016 in “Journal of the European Academy of Dermatology and Venereology” Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.
124 citations
,
December 2016 in “Pharmaceuticals” This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.
277 citations
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July 2011 in “Journal of the Dermatology Nurses’ Association” The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.
2 citations
,
October 2013 in “Journal of Veterinary Internal Medicine” This study reports the first documented case of sweat hypersensitivity and progressive sebaceous adenitis in a horse, highlighting the potential for sweat-induced urticaria when exercising or under sedation.
12 citations
,
June 2020 in “Sultan Qaboos University medical journal” This review discusses the role of the TRPV4 channel in skin physiology and pathology, highlighting its potential as a therapeutic target for skin disorders, but reports no new clinical results.
6 citations
,
May 2024 in “PLoS ONE” In this study, content analysis of German YouTube videos revealed that women frequently experience both positive and negative symptoms related to oral contraceptive use and discontinuation, with bodily sensations often influencing their decisions to start or stop the pill.
4 citations
,
November 2014 The skin protects the body, regulates temperature, senses touch, and makes vitamin D.
38 citations
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March 2019 in “International Wound Journal” In this study, a new cell-tissue technology using a patient's own skin to create a full-thickness skin autograft successfully treated a chronic wound larger than 200 cm², achieving complete functional skin coverage within 12 weeks and maintaining results at a 6-month follow-up.
April 2019 in “Journal of Investigative Dermatology” This study found that, in mice, different precursor populations give rise to Merkel cells in hairy versus glabrous skin, but their formation is controlled by a common genetic program involving FGFR2 signaling.
19 citations
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February 2016 in “Journal of Biological Chemistry” In this study, researchers observed that knocking out KCNQ3 in mice increased firing frequencies in response to stimuli, particularly at slow mechanical indentation velocities, indicating a role in mechanosensory neuron sensitivity.
This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.