In Vivo Expansion and Regeneration of Full-Thickness Functional Skin with an Autologous Homologous Skin Construct: Clinical Proof of Concept for Chronic Wound Healing
March 2019
in “
International Wound Journal
”
TLDR A new skin treatment using a patient's own cells healed chronic wounds effectively and was preferred over traditional grafts.
The study provided clinical proof of concept for using an autologous homologous skin construct (AHSC) to treat chronic wounds unresponsive to traditional methods. AHSC, derived from a patient's own skin cells, was applied to a large non-healing wound, achieving complete epithelial coverage in 8 weeks and full-thickness functional skin by 12 weeks. At a 6-month follow-up, the regenerated skin was similar to native skin in sensation and hair follicle morphology. The patient preferred AHSC over split-thickness skin grafts for reduced pain and improved function and appearance. The study suggested AHSC as a promising treatment for chronic wounds, though further research was needed for patients with comorbidities.
