Most American men experience hair loss by age 50, with limited effective treatments available and new options not expected soon.
August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists improved how to make skin-like structures from stem cells using special gels and a device that controls growth signals, leading to better hair and skin features.
May 2020 in “Research Square (Research Square)” The study identified key genes that align with the cashmere growth cycle in goats, which could help improve cashmere production timing.
January 2018 in “Stem cell biology and regenerative medicine” ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
December 2022 in “Journal of Investigative Dermatology” Minoxidil and PRP can help convert miniaturized hair follicles back to normal in male pattern baldness.
January 2014 in “프로그램북(구 초록집)” Male pattern hair loss (MPHL), affecting about 50% of both sexes, is linked to the enzyme 5-alpha reductase (5AR), which converts testosterone to dihydrotestosterone, a key factor in hair loss. There are three isoenzymes of 5AR, with type 1 found in skin and hair follicles, and type 2 in male genitalia and hair follicles. Treatments include topical minoxidil and oral finasteride, a type 2 5AR inhibitor, which significantly improves hair growth and slows hair loss. Dutasteride, a dual inhibitor of type 1 and 2 5AR, has shown efficacy in treating benign prostatic hyperplasia and androgenetic alopecia, with a 2009 study in Korea demonstrating significant hair growth improvement. The lecture aimed to provide updates on 5AR inhibitors for better understanding and treatment of MPHL.
96 citations,
December 2002 in “Experimental dermatology” NGAL indicates abnormal skin cell differentiation.
86 citations,
May 2002 in “Journal of comparative neurology” Nerve growth in mouse skin and hair follicles happens in stages and is closely linked to hair development.
2 citations,
January 2018 in “Springer eBooks” The document explains what healthy skin, nails, and hair look like on an ultrasound.
1 citations,
February 2016 in “Cell Transplantation” Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.
1 citations,
September 2013 in “The Journal of Dermatology” An 8-year-old girl developed a rare skin condition in a linear pattern on one side of her body after a lung infection, which improved with treatment.
January 2023 in “Open Life Sciences” VEGFR-2 activation is likely involved in hair follicle growth, survival, and development.
August 2022 in “Journal of Investigative Dermatology” Dkk4 is necessary for the initial development and arrangement of hair follicles.
September 2020 in “Research Square (Research Square)” Goat skin adapts to seasonal changes through genes that respond to daylight length, affecting hormone levels and potentially making skin cells light-sensitive.
91 citations,
July 2020 in “JAMA Dermatology” Minoxidil can improve hair growth in some patients with woolly hair due to LIPH variants, with varying responses and mild side effects.
7 citations,
June 2015 in “Cutaneous and Ocular Toxicology” Some drugs can cause skin reactions, which may improve when the drug is stopped, and rapid diagnosis and stopping the drug is crucial.
January 2014 in “International Journal of Case Reports and Images” A woman with undifferentiated connective tissue disease was diagnosed with renal amyloidosis and carpal tunnel syndrome.
August 2023 in “Journal of Investigative Dermatology” This study conducted scRNA-seq on 96 biopsies from 51 healthy individuals across 7 anatomic sites to understand skin biology and cell-cell interactions. Analyzing 274,834 cells, with a focus on 87,213 keratinocytes, the researchers identified 36 significant signaling pathways, 11 of which were common across all sites. Unique pathways were found in facial and palmoplantar skin, with palmoplantar skin showing enriched Tenascin signaling and lacking PARs and MIF signaling, while facial skin exhibited significant WNT, TGFb, and TRAIL pathway activity. These findings highlight distinct cell-cell communication patterns that may explain the predisposition to specific skin diseases in different body regions.
70 citations,
November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
4 citations,
January 2012 in “Springer eBooks” The document concludes that signs of male and female pattern baldness include uneven hair thickness, yellow spots, skin discoloration around hair follicles, more thin and soft hairs, and many hair follicles with just one hair.
December 2021 in “Journal of clinical images and medical case reports” Moth-eaten alopecia is linked to various skin diseases and requires early treatment to prevent worsening.
November 2017 in “British Journal of Dermatology” Organ transplant recipients have a higher risk of skin cancer over time, atopic dermatitis skin shows unusual bacterial and fungal patterns, a new tool for measuring hidradenitis suppurativa severity was created, and gene expression changes in male baldness suggest new treatments.
November 1993 in “PubMed” Hirsutism, excessive male-pattern hair in women, can be caused by high androgens or skin sensitivity, diagnosed by testosterone levels, and treated with hair removal and hormone therapy.
December 2022 in “Nature Communications” The study introduces a bead-jet printing system for sparse mesenchymal stem cell (MSC) patterning, significantly enhancing skeletal muscle and hair follicle regeneration. Using Matrigel beads to encapsulate MSCs, the system improves cell retention, proliferation, and migration compared to traditional methods. High-density MSCs in sparse patterns among acellular beads provide superior therapeutic outcomes, reducing the number of MSCs needed for effective treatment. The method activates the PI3K-Akt and Wnt/β-CATENIN signaling pathways, leading to better muscle regeneration with less fibrosis and improved skin healing with increased hair follicle formation. The findings suggest that bead-jet printing of MSCs in high-density patterns can significantly enhance tissue regeneration outcomes, making it a promising approach for large-scale traumatic injury therapy.
66 citations,
February 2013 in “Pediatric Dermatology” Dermoscopy improves diagnosis and treatment monitoring for children's skin infections, inflammations, and hair disorders.
18 citations,
October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft” Accurate diagnosis and combined antibiotic treatment are crucial for Staphylococcus aureus skin infections.
9 citations,
January 2017 in “Virchows Archiv” LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.
2 citations,
November 2023 in “JMIR. Journal of medical internet research/Journal of medical internet research” Machine learning can predict symptoms and quality of life in chronic skin disease patients using smartphone app data, and shows that app use varies with patient characteristics.
2 citations,
October 2023 in “Dermatology practical & conceptual” More research is needed to understand hair and scalp disorders in people with skin of color.
1 citations,
January 2016 in “Asian-Australasian journal of animal sciences” The protein Gnαs is found more in black mice than white mice and may influence their coat color.