Translation-Dependent Skin Hyperplasia Promoted by Type 1/17 Inflammation in Psoriasis
April 2023
in “
Journal of Investigative Dermatology
”
eIF4E keratinocytes psoriasis vulgaris epidermis murine model psoriasis-like dermatitis imiquimod cytokines IFN-γ IL-17A TNF-α NHEK 4EGI-1 type 1/17 inflammation initiation factor skin cells psoriasis skin layer mouse model skin inflammation topical treatment immune proteins interferon gamma interleukin 17A tumor necrosis factor alpha normal human epidermal keratinocytes eIF4E inhibitor inflammatory response
TLDR Type 1/17 inflammation in psoriasis increases skin cell growth due to a molecule that could be a new treatment target.
The study "1326 Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis" investigates the role of the molecule initiation factor (eIF4E) in the proliferation of keratinocytes in psoriasis. The research found that skin lesions from patients with psoriasis vulgaris (PV) showed a higher expression of eIF4E, which was positively correlated with the thickness of the epidermis. This pattern was also observed in a murine model of psoriasis-like dermatitis induced by topical imiquimod. The study also found that the cytokines IFN-γ and IL-17A, but not TNF-α, were sufficient to induce proliferation of normal human epidermal keratinocytes (NHEK) in vitro, an effect that could be disrupted by 4EGI-1, an inhibitor of eIF4E activities. The conclusion is that eIF4E plays a crucial role in keratinocyte proliferation driven by type 1/17 inflammation in psoriasis, suggesting that abnormal translation initiation could be a potential treatment target for psoriasis.
