88 citations
,
May 2020 in “Clinical therapeutics” This review discusses the role of stress mediators in skin diseases and reports no new clinical results; the authors suggest further research in skin psychoneuroimmunology.
84 citations
,
February 2015 in “Experimental Dermatology” This review discusses the role of PPARs in skin health, suggesting both potential benefits and adverse effects, but reports no new experimental results; the authors emphasize the need for more research to understand these pathways.
78 citations
,
January 2000 in “Gynecological Endocrinology” This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.
61 citations
,
March 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that 43.35% of the adult population across 27 European countries reported having a skin condition in the past year, highlighting the need for dermatological care planning.
61 citations
,
February 2017 in “International Journal of Women’s Dermatology” This review discusses skin disorders in women of color, highlighting unique presentations like dyschromias from acne, and underscores the need for more research on racial and ethnic differences; it reports no new clinical results.
55 citations
,
March 2018 in “Journal of pharmacy & pharmaceutical sciences” This article reviews the applications of microneedle technology in drug delivery, dermatology, and cosmetics, but it presents no new experimental or clinical findings.
48 citations
,
September 2009 in “Dermato-endocrinology” This article reviews skin signs in patients with anorexia nervosa and their potential role in early diagnosis but reports no clinical results; it emphasizes the importance of dermatologists in recognizing these signs.
48 citations
,
January 2000 in “Hormone Research in Paediatrics” This article reviews the regulation of androgens in human skin and adrenals, highlighting their role in skin disorders, but reports no new research findings.
42 citations
,
August 2016 in “Nanomedicine” In this study, TyroSpheres were used to encapsulate adapalene, increasing its solubility and enhancing skin distribution while reducing irritancy compared to a commercial formulation, indicating promise for acne treatment in ex vivo and in vitro settings.
40 citations
,
May 2010 in “American Journal of Clinical Dermatology” This study reports that four Indian patients with acne keloidalis nuchae also exhibited acanthosis nigricans, suggesting a potential link to metabolic syndrome, though further research is needed to confirm this association.
31 citations
,
November 2020 in “International journal of molecular sciences” This review discusses the role of adipokines in skin physiology and pathology, suggesting they may influence skin conditions and diseases through interaction with various skin cell types, but reports no new clinical results.
28 citations
,
January 2006 in “Journal of agricultural safety and health” This study found that skin disease, particularly fungal infections, is prevalent among Latino farmworkers in North Carolina, with no significant differences observed between workers at two different camps.
25 citations
,
February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, topical application of the SCD1 inhibitor XEN103 significantly reduced sebaceous gland size and number in mouse skin, suggesting potential local therapeutic effects for acne treatment without systemic side effects.
21 citations
,
June 2004 in “International Journal of Dermatology” This study found that over half of skin diseases observed in Yemen, particularly in Hajjah, were dermatitis and eczematous disorders, and infections, suggesting the influence of local socioeconomic and environmental factors.
21 citations
,
January 1988 in “Stress Medicine” This review discusses the developmental and psychological significance of skin and emphasizes the need for considering stress effects when evaluating and treating psychocutaneous diseases, without reporting new clinical results.
19 citations
,
February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
19 citations
,
January 2015 in “Indian Journal of Dermatology” In this study, researchers observed that 90% of patients with PCOS had cutaneous manifestations, with acne most common, and found associations between these skin conditions and high insulin or testosterone levels.
19 citations
,
October 2008 in “Journal der Deutschen Dermatologischen Gesellschaft” This article reviews the cutaneous reactions and characteristic skin changes associated with chemotherapy, radiation therapy, and new targeted cancer treatments, reporting no new clinical results.
18 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review summarizes the positive clinical response of using platelet-rich plasma as an adjuvant in skin rejuvenation treatments, with no identifiable complications, suggesting a promising outlook for its future use.
18 citations
,
October 2014 in “Experimental Dermatology” Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.
17 citations
,
July 2017 in “International Journal of Behavioral Medicine” This study validated the Egyptian Arabic version of the Skindex-16 and found that skin conditions significantly impacted patients' quality of life, particularly in the emotional domain.
16 citations
,
March 2025 in “International Journal of Molecular Sciences” This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.
14 citations
,
December 2013 in “Experimental Dermatology” The T-zone on the face has more androgen receptors and produces more oil than the U-zone.
12 citations
,
March 2022 in “Frontiers in Nutrition” This review discusses the complex skin changes associated with obesity and the potential benefits of nutritional interventions for inflammatory skin diseases, without reporting new clinical results.
12 citations
,
May 2017 in “Journal of Dermatological Treatment” This study found that in adults over 25, stress from lifestyle changes, sensitive skin, stopping oral contraceptives, and the use of full-coverage foundations were associated with increased severity of acne.
12 citations
,
November 2012 in “BioMolecular Concepts” This review discusses the diverse roles of PPARβ/δ in skin health and disease, including its involvement in skin wound healing and inflammatory skin conditions, without presenting new experimental results.
10 citations
,
March 2021 in “International Journal of Environmental Research and Public Health” This study found that Google users are increasingly searching for health information on dermatological issues, with particular interest in itch, hair loss, and skin rash.
10 citations
,
June 2011 in “PubMed” This article suggests that most topical treatments for acne and unwanted hair growth are safe to use during pregnancy, except for hydroquinone and tretinoin, due to low systemic absorption.
9 citations
,
January 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses acne vulgaris, its causes, and impacts without presenting new findings; the authors note anxiety and depression in acne patients are not linked to oxidative stress.
8 citations
,
May 2023 in “PubMed” This review discusses emerging drug delivery technologies and formulations for acne and rosacea, noting that microencapsulation enables combining benzoyl peroxide and tretinoin to enhance tolerability and prevention of oxidation.