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Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Working night shifts for four days can lower the body's ability to use insulin, which may increase the risk of type 2 diabetes.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

A boy with severe Vitamin D-resistant rickets did not respond to treatment and lacked a common symptom, suggesting a need for alternative treatments.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

Minoxidil lowers blood pressure, increases heart rate, and improves blood flow in dogs.

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

Spironolactone may help enlarge a small breast linked to Becker's nevus.

Finasteride doesn't affect bone density in male rats.

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.

Mice can regenerate ear tissue without the p53 protein.

Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.

Pro-IGF-II improves muscle repair in old mice.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.

Combining cosmetic procedures with lifestyle changes improves antiaging results.

Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.

New culture method keeps human skin stem cells more stem-like.

Women experience various skin issues at different life stages, requiring careful treatment and awareness.